The Netherlands Cancer Institute

The Netherlands Cancer Institute (NKI) is a dedicated cancer centre in The Netherlands, placed at the international forefront of both patient treatment and cancer research.

To enable preclinical in-vivo modelling and treatment of cancer, the NKI has established the Mouse Clinic for Cancer and Ageing (MCCA), which houses a transgenic facility and a mouse cancer clinic.

The MCCA Transgenic Facility provides all services related to the generation of genetically engineered mouse models (GEMMs) and has developed novel pipelines for the accelerated production of models using CRISPR/Cas9-based gene editing as well as GEMMs-derived embryonic stem cells (GEMM-ESCs). A unique archive for the distribution of GEMM-ESC lines has been created as part of the EMMA project.

The MCCA Mouse Cancer Clinic performs preclinical intervention and imaging studies using advanced cancer models, such as transgenic models, orthotopic transplantation models, and patient derived xenografts (PDX).