The Netherlands Cancer Institute

Services:

Mouse model development
GEMM-ESC archive

Address:
Plesmanlaan 121
1066 CX Amsterdam
The Netherlands
Web: www.nki.nl

Contact person:
Prof Dr Jos Jonkers
Head of Division of Molecular Pathology

Dr Marieke van de Ven
Head of Mouse Cancer Clinic

Email:
z.iq.ira@axv.ay

The Netherlands Cancer Institute (NKI) is a dedicated cancer centre in The Netherlands, placed at the international forefront of both patient treatment and cancer research.

To enable preclinical in-vivo modelling and treatment of cancer, the NKI has established the Mouse Clinic for Cancer and Ageing (MCCA), which houses a transgenic facility and a mouse cancer clinic.

The MCCA Transgenic Facility provides all services related to the generation of genetically engineered mouse models (GEMMs) and has developed novel pipelines for the accelerated production of models using CRISPR/Cas9-based gene editing as well as GEMMs-derived embryonic stem cells (GEMM-ESCs). A unique archive for the distribution of GEMM-ESC lines has been created as part of the EMMA project.

The MCCA Mouse Cancer Clinic performs preclinical intervention and imaging studies using advanced cancer models, such as transgenic models, orthotopic transplantation models, and patient derived xenografts (PDX).

Matching News

Event October 2, 2024

The INFRAPLUS Project Successfully Launched in Munich

The INFRAPLUS’s kick-off took place over two productive days in Munich. With lively discussions and concrete plans, we have set the stage for INFRAFRONTIER’s expansion in state-of-the-art in vivo models, innovative in vitro models, preclinical services, and data analysis. All set to get started!

Scientific Publication July 24, 2024

OBSERVE: Guidelines for the Refinement of Rodent Cancer Models

Our partners at NKI and colleagues have developed the OBSERVE guidelines to improve the preparation and reporting of in vivo cancer studies in rodents. The guidelines provide detailed instructions on optimal preparation, implantation methods, and monitoring criteria. They also address expected adverse effects and offer tools to minimise distress and pain in animal models, promoting ethical practices and animal welfare in cancer research.

Highlight October 20, 2023

canSERV Open Call Invites Cancer Researchers to Apply for Free State-of-the-Art Services and Training

Under the canSERV Open Call, researchers are invited to apply for a portfolio of services covering the entire oncology developmental pipeline, with the participation of 9 INFRAFRONTIER partners providing in vivo services. Deadline: 4 January 2023

Scientific Publication July 24, 2023

New INFRAFRONTIER Article Published in Journal Mammalian Genome

A new publication of INFRAFRONTIER in Mammalian Genome is available on line now. Get an overview of the latest INFRAFRONTIER advancements, including services, resources, and technical developments.

Training April 8, 2021

IMM2021 workshop held virtually in June 2021

Famous mouse model workshop in Leiden has opened its online registration. The Innovative Mouse Models workshop IMM2021 in Leiden has a long history and is highly acknowledged among biomedical and genetic scientists worldwide. Due to the pandemic situation in Europe, the famous mutant mouse workshop, traditionally held at the Leiden University Medical Center (LUMC) and co-organized by INFRAFRONTIER´s Dutch partner institute NKI, will be presented as a virtual meeting this year for the first time.