C57BL/6N-A^tm1Brd Ackr3^{tm2a(EUCOMM)Wtsi}/IcsOrl

Status	Available to order
EMMA ID	EM:09984
International strain name	C57BL/6N-A^tm1Brd Ackr3^{tm2a(EUCOMM)Wtsi}/IcsOrl
Alternative name	EPD0830_1_D06
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Ackr3^{tm2a(EUCOMM)Wtsi}
Gene/Transgene symbol	Ackr3
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	This mouse line originates from EUCOMM ES clone EPD0830_1_D06. For further details on the construction of this clone see the page at the IKMC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France
Animals used for archiving	heterozygous C57BL/6NTac

Disease and phenotype information

IMPC phenotypes (gene matching)

decreased grip strength / IMPC
preweaning lethality, complete penetrance / IMPC
increased mean corpuscular hemoglobin concentration / IMPC
decreased total retina thickness / IMPC
tremors / IMPC

MGI phenotypes (gene matching)

abnormal heart morphology / MGI
overriding aortic valve / MGI
enlarged heart / MGI
heart hyperplasia / MGI
abnormal interventricular septum morphology / MGI
abnormal atrioventricular cushion morphology / MGI
abnormal cardiovascular system physiology / MGI
cyanosis / MGI
abnormal blood vessel morphology / MGI
abnormal atrial thrombosis / MGI
lung inflammation / MGI
hemorrhage / MGI
respiratory distress / MGI
premature death / MGI
abnormal semilunar valve morphology / MGI
abnormal aortic valve morphology / MGI
abnormal pulmonary valve morphology / MGI
dilated heart right ventricle / MGI
dilated heart atrium / MGI
cardiac fibrosis / MGI
nervous system phenotype / MGI
myocardial fiber degeneration / MGI
digestive/alimentary phenotype / MGI
immune system phenotype / MGI
hematopoietic system phenotype / MGI
pulmonary fibrosis / MGI
calcified aortic valve / MGI
aortic valve stenosis / MGI
abnormal cardiac outflow tract development / MGI
pulmonary valve stenosis / MGI
decreased marginal zone B cell number / MGI
decreased survivor rate / MGI
ventricular septal defect / MGI
atrial septal defect / MGI
perimembraneous ventricular septal defect / MGI
abnormal heart and great artery attachment / MGI
thick aortic valve / MGI
thick pulmonary valve / MGI
postnatal lethality, incomplete penetrance / MGI
neonatal lethality, complete penetrance / MGI
neonatal lethality, incomplete penetrance / MGI
perinatal lethality, complete penetrance / MGI
perinatal lethality, incomplete penetrance / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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