C57BL/6N-A^tm1Brd Satb1^{tm1a(EUCOMM)Hmgu}/IcsOrl

Status	Available to order
EMMA ID	EM:09962
International strain name	C57BL/6N-A^tm1Brd Satb1^{tm1a(EUCOMM)Hmgu}/IcsOrl
Alternative name	HEPD0534_5_E11
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Satb1^{tm1a(EUCOMM)Hmgu}
Gene/Transgene symbol	Satb1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	This mouse line originates from EUCOMM ES clone HEPD0534_5_E11. For further details on the construction of this clone see the page at the IKMC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France
Animals used for archiving	heterozygous C57BL/6NTac

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Non-specific syndromic intellectual disability / Orphanet_528084

IMPC phenotypes (gene matching)

increased circulating aspartate transaminase level / IMPC
hyperactivity / IMPC
abnormal bone structure / IMPC
abnormal auditory brainstem response / IMPC
increased bone mineral content / IMPC
preweaning lethality, incomplete penetrance / IMPC
increased exploration in new environment / IMPC
abnormal vitreous body morphology / IMPC
preweaning lethality, complete penetrance / IMPC

MGI phenotypes (allele matching)

postnatal growth retardation / MGI
nervous system phenotype / MGI
abnormal brain interneuron morphology / MGI
postnatal lethality, complete penetrance / MGI

MGI phenotypes (gene matching)

small spleen / MGI
small thymus / MGI
decreased thymocyte number / MGI
decreased body size / MGI
delayed eyelid opening / MGI
limb grasping / MGI
postnatal growth retardation / MGI
arrested T cell differentiation / MGI
abnormal T cell differentiation / MGI
small lymph nodes / MGI
abnormal CD4-positive, alpha beta T cell morphology / MGI
nervous system phenotype / MGI
abnormal brain interneuron morphology / MGI
abnormal CD8-positive, alpha beta T cell morphology / MGI
abnormal T cell proliferation / MGI
postnatal lethality, complete penetrance / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
LacZ tagged null allele (tm1b allele), service fee and delivery time available upon request
Conditional ready allele (tm1c allele), service fee and delivery time available upon request
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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