IMPC phenotypes (gene matching)
C57BL/6-Atm1Brd Lpar1tm1c(EUCOMM)Wtsi/Flmg
| Status | Available to order |
| EMMA ID | EM:09947 |
| International strain name | C57BL/6-Atm1Brd Lpar1tm1c(EUCOMM)Wtsi/Flmg |
| Alternative name | B6-Lpar1 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Lpar1tm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Lpar1 |
Information from provider
| Provider | Vassilis Aidinis |
| Provider affiliation | Institute of Immunology, B.S.R.C. Al. Fleming |
| Genetic information | This allele was derived from the B6-Lpar1tm1a(EUCOMM)Wtsi/Flmg line (EMMA strain EM:09092), by removing the FRT-flanked LacZ and neomycin selection cassette via flp-mediated recombination. The resulting allele has exon 3 (2nd coding exon; ENSMUSE00001261995) flanked by loxP sites providing conditionality. The absence of the LacZ and neomycin cassette was confirmed by PCR. |
| Phenotypic information | Homozygous:No overt phenotype.Heterozygous:No overt phenotype. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous C57BL/6 |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- abnormal craniofacial morphology / MGI
- short snout / MGI
- exencephaly / MGI
- abnormal Schwann cell morphology / MGI
- decreased Schwann cell number / MGI
- decreased body height / MGI
- decreased body weight / MGI
- decreased body size / MGI
- ocular hypertelorism / MGI
- hypoactivity / MGI
- abnormal suckling behavior / MGI
- postnatal growth retardation / MGI
- increased dopamine level / MGI
- hemorrhage / MGI
- abnormal sciatic nerve morphology / MGI
- nervous system phenotype / MGI
- long incisors / MGI
- abnormal serotonin level / MGI
- abnormal amino acid level / MGI
- decreased body mass index / MGI
- decreased prepulse inhibition / MGI
- decreased total body fat amount / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- decreased body fat mass / MGI
Literature references
- Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy.;Ray Rashmi, Sinha Sunita, Aidinis Vassilis, Rai Vivek, ;2021;Cell reports;34;108809; 33657371