B6NCrl;B6N-Atm1Brd Nrp1tm1a(EUCOMM)Hmgu/CipheOrl

Status

Available to order

EMMA IDEM:09943
International strain nameB6NCrl;B6N-Atm1Brd Nrp1tm1a(EUCOMM)Hmgu/CipheOrl
Alternative nameHEPD0725_5_F02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolNrp1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolNrp1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Centre d'ImmunoPhenomique - Ciphe
Provider affiliationCentre d'ImmunoPhenomique - Ciphe
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0725_5_F02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NCrl

Disease and phenotype information

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
  • decreased prepulse inhibition / IMPC
  • abnormal auditory brainstem response / IMPC
MGI phenotypes (gene matching)
  • abnormal vascular development / MGI
  • abnormal pulmonary artery morphology / MGI
  • abnormal corpus callosum morphology / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal facial motor nucleus morphology / MGI
  • abnormal dorsal root ganglion morphology / MGI
  • abnormal cranial nerve morphology / MGI
  • abnormal trigeminal nerve morphology / MGI
  • abnormal facial nerve morphology / MGI
  • abnormal vestibulocochlear nerve morphology / MGI
  • abnormal spinal nerve morphology / MGI
  • decreased body size / MGI
  • disorganized yolk sac vascular plexus / MGI
  • postnatal growth retardation / MGI
  • postnatal lethality / MGI
  • premature death / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal T cell physiology / MGI
  • persistent truncus arteriosis / MGI
  • abnormal pharyngeal arch artery morphology / MGI
  • abnormal retinal vasculature morphology / MGI
  • abnormal axon guidance / MGI
  • dilated heart atrium / MGI
  • decreased tumor growth/size / MGI
  • nervous system phenotype / MGI
  • vascular smooth muscle hypoplasia / MGI
  • transposition of great arteries / MGI
  • abnormal coronary artery morphology / MGI
  • right aortic arch / MGI
  • double aortic arch / MGI
  • abnormal dorsal aorta morphology / MGI
  • abnormal brain vasculature morphology / MGI
  • cardiovascular system phenotype / MGI
  • vision/eye phenotype / MGI
  • decreased angiogenesis / MGI
  • abnormal neuronal migration / MGI
  • abnormal fourth pharyngeal arch artery morphology / MGI
  • abnormal sixth pharyngeal arch artery morphology / MGI
  • abnormal third pharyngeal arch artery morphology / MGI
  • abnormal induced retinal neovascularization / MGI
  • abnormal retinal blood vessel morphology / MGI
  • abnormal retinal blood vessel pattern / MGI
  • abnormal first pharyngeal arch artery morphology / MGI
  • abnormal second pharyngeal arch artery morphology / MGI
  • abnormal aortic arch and aortic arch branch attachment / MGI
  • abnormal coronary vessel morphology / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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