B6N.Cg-Stat1^tm1Dlv Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} Col1a1^{tm1(tetO-Stat1)Biat}/Biat

Status	Available to order
EMMA ID	EM:09938
International strain name	B6N.Cg-Stat1^tm1Dlv Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} Col1a1^{tm1(tetO-Stat1)Biat}/Biat
Alternative name	C57BL/6N-Stat1, Gt(ROSA)26Sor, Col1a1
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Stat1^tm1Dlv, Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} , Col1a1^{tm1(tetO-Stat1)Biat}
Gene/Transgene symbol	Stat1, Gt(ROSA)26Sor, Col1a1

Information from provider

Provider	Mathias Müller
Provider affiliation	Department for Biomedical Sciences, University of Veterinary Medicine Vienna (Vetmeduni Vienna)
Additional owner	Prof. Thomas Rülicke, University of Veterinary Medicine, Institute of Laboratory Animal Science, Vienna, Austria
Genetic information	Stat1^tm1Dlv: A neomycin resistance cassette replaced 5.7 kb of sequence, including 3 exons and a portion of a fourth encoding amino acids 221-365. This allele produces a partial nonfunctional protein product. (J:31325) Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}: An optimized form of reverse tetracycline controlled transactivator (rtTA-M2) was inserted downstream of the Gt(ROSA)26Sor promoter and was followed by a PGK-puro selection cassette. This mutant form of rtTA termed M2 has five amino acid substitutions in the tetR moiety of tTA: S12G, E19G, A56P, D148E and H179R. This mutated form of transactivatory protein has increased doxycycline sensitivity. Mice have widespread expression of the rtTA-M2 protein. (J:98920) Col1a1^{tm1(tetO-Stat1)Biat}: RMCE on KH2 ES cells introduced into the 3' UTR a tetracycline responsive element driving inducible expression of the FLAG-tagged mouse cDNA. (J:212694)
Phenotypic information	Homozygous: n/a Heterozygous: immunological phenotype - see paper
Breeding history	The mice were backcrossed to the C57BL/6N background by speed congenics (Teppner et al. 2004; Lab Anim. 38:406–412. 10.1258/0023677041958882).
References	Inducible, dose-adjustable and time-restricted reconstitution of STAT1 deficiency in vivo.;Leitner Nicole R, Lassnig Caroline, Rom Rita, Heider Susanne, Bago-Horvath Zsuzsanna, Eferl Robert, Müller Simone, Kolbe Thomas, Kenner Lukas, Rülicke Thomas, Strobl Birgit, Müller Mathias, ;2014;PloS one;9;e86608; 24489749
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	not known

Information from EMMA

Archiving centre	University of Veterinary Medicine, Vienna, Austria
Animals used for archiving	homozygous C57BL/6N
Breeding at archiving centre	Breeding of animals for homozygous embryo production

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Ehlers-Danlos/osteogenesis imperfecta syndrome / Orphanet_230857
Osteogenesis imperfecta type 3 / Orphanet_216812
Arthrochalasia Ehlers-Danlos syndrome / Orphanet_1899
Classical Ehlers-Danlos syndrome / Orphanet_287
Osteogenesis imperfecta type 2 / Orphanet_216804
Osteogenesis imperfecta type 4 / Orphanet_216820
Caffey disease / Orphanet_1310
High bone mass osteogenesis imperfecta / Orphanet_314029
Osteogenesis imperfecta type 1 / Orphanet_216796
Autoimmune enteropathy and endocrinopathy-susceptibility to chronic infections syndrome / Orphanet_391487
Susceptibility to viral and mycobacterial infections due to STAT1 deficiency / Orphanet_391311
Mendelian susceptibility to mycobacterial diseases due to partial STAT1 deficiency / Orphanet_319595

IMPC phenotypes (gene matching)

abnormal posture / IMPC
increased monocyte cell number / IMPC
decreased mean corpuscular hemoglobin / IMPC
increased neutrophil cell number / IMPC
increased lymphocyte cell number / IMPC
abnormal gait / IMPC
impaired righting response / IMPC
decreased mean corpuscular volume / IMPC
enlarged lymph nodes / IMPC
decreased lymphocyte cell number / IMPC
decreased bone mineral content / IMPC
increased leukocyte cell number / IMPC
decreased circulating alkaline phosphatase level / IMPC
increased large unstained cell number / IMPC
increased eosinophil cell number / IMPC
increased basophil cell number / IMPC

MGI phenotypes (allele matching)

increased mammary adenocarcinoma incidence / MGI
impaired natural killer cell mediated cytotoxicity / MGI
increased circulating interferon-gamma level / MGI
increased circulating interleukin-12b level / MGI
abnormal NK cell physiology / MGI
decreased level of surface class I molecules / MGI
increased susceptibility to bacterial infection / MGI
increased susceptibility to viral infection / MGI
abnormal MHC II cell surface expression on macrophages / MGI
vision/eye phenotype / MGI
decreased susceptibility to endotoxin shock / MGI
abnormal intestine morphology / MGI
decreased body size / MGI
multifocal hepatic necrosis / MGI
abnormal leukocyte physiology / MGI
lethality at weaning, complete penetrance / MGI

MGI phenotypes (gene matching)

abnormal adipose tissue distribution / MGI
big ears / MGI
delayed bone ossification / MGI
fragile skeleton / MGI
increased bone mineral density / MGI
decreased bone mineral density / MGI
failure of bone resorption / MGI
osteopetrosis / MGI
kyphoscoliosis / MGI
abnormal neurocranium morphology / MGI
decreased compact bone thickness / MGI
abnormal vertebral body morphology / MGI
abnormal rib morphology / MGI
kyphosis / MGI
scoliosis / MGI
heart right ventricle hypertrophy / MGI
increased cell proliferation / MGI
abnormal cell morphology / MGI
focal hair loss / MGI
abnormal cranium morphology / MGI
abnormal maxilla morphology / MGI
abnormal digestive system morphology / MGI
abnormal forelimb morphology / MGI
abnormal femur morphology / MGI
syndactyly / MGI
oligodactyly / MGI
abnormal autopod morphology / MGI
thin tail / MGI
abnormal liver morphology / MGI
weakness / MGI
hindlimb paralysis / MGI
abnormal uterus morphology / MGI
lung hemorrhage / MGI
thick skin / MGI
skin hyperplasia / MGI
abnormal dermal layer morphology / MGI
thick dermal layer / MGI
increased body length / MGI
decreased body length / MGI
increased body weight / MGI
decreased body weight / MGI
increased body size / MGI
decreased body size / MGI
abnormal tail movements / MGI
abnormal locomotor behavior / MGI
hypoactivity / MGI
abnormal gait / MGI
abnormal motor coordination/balance / MGI
abnormal osteoclast physiology / MGI
abnormal cardiovascular system physiology / MGI
abnormal blood vessel morphology / MGI
embryonic growth arrest / MGI
lung inflammation / MGI
hemorrhage / MGI
intracranial hemorrhage / MGI
increased litter size / MGI
decreased litter size / MGI
delayed sexual maturation / MGI
respiratory distress / MGI
abnormal coat/hair pigmentation / MGI
premature death / MGI
abnormal limb morphology / MGI
abnormal digit morphology / MGI
abnormal limb bone morphology / MGI
abnormal fertility/fecundity / MGI
no abnormal phenotype detected / MGI
abnormal fibula morphology / MGI
abnormal turbinate morphology / MGI
decreased susceptibility to hepatic steatosis / MGI
abnormal blood gas level / MGI
delayed vaginal opening / MGI
decreased circulating insulin level / MGI
abnormal mechanical nociception / MGI
decreased vertical activity / MGI
abnormal dental pulp cavity morphology / MGI
coarse hair / MGI
increased growth rate / MGI
increased insulin sensitivity / MGI
abnormal bone mineralization / MGI
increased circulating parathyroid hormone level / MGI
decreased circulating alkaline phosphatase level / MGI
arthritis / MGI
abnormal bone healing / MGI
no phenotypic analysis / MGI
decreased skin tensile strength / MGI
decreased tendon stiffness / MGI
short femur / MGI
decreased susceptibility to age related obesity / MGI
aneurysm / MGI
osteoarthritis / MGI
abnormal long bone morphology / MGI
abnormal compact bone morphology / MGI
abnormal forelimb zeugopod morphology / MGI
increased hepatocyte proliferation / MGI
abnormal hormone level / MGI
increased lean body mass / MGI
decreased thermal nociceptive threshold / MGI
decreased bone mass / MGI
aortic dissection / MGI
abnormal chest morphology / MGI
abnormal pubis morphology / MGI
abnormal ischium morphology / MGI
abnormal pelvic girdle bone morphology / MGI
thin ribs / MGI
rib fractures / MGI
decreased length of long bones / MGI
abnormal vertebral column morphology / MGI
short vertebral body / MGI
increased susceptibility to age-related hearing loss / MGI
abnormal osteoblast morphology / MGI
increased osteoblast cell number / MGI
decreased bone strength / MGI
increased bone resorption / MGI
abnormal osteoblast physiology / MGI
liver hyperplasia / MGI
decreased susceptibility to injury / MGI
ocular hypertension / MGI
improved glucose tolerance / MGI
abnormal humerus morphology / MGI
abnormal enzyme/coenzyme level / MGI
abnormal myocardium layer morphology / MGI
homeostasis/metabolism phenotype / MGI
hearing/vestibular/ear phenotype / MGI
digestive/alimentary phenotype / MGI
reproductive system phenotype / MGI
skeleton phenotype / MGI
vision/eye phenotype / MGI
decreased percent body fat/body weight / MGI
abnormal skeleton morphology / MGI
decreased circulating glucose level / MGI
decreased ventricle muscle contractility / MGI
decreased susceptibility to diet-induced obesity / MGI
spinal hemorrhage / MGI
abnormal heart septum morphology / MGI
impaired hearing / MGI
decreased diameter of femur / MGI
abnormal myometrium morphology / MGI
abnormal osteoblast differentiation / MGI
abnormal cutaneous collagen fibril morphology / MGI
abnormal osteocyte morphology / MGI
fused carpal bones / MGI
delayed female fertility / MGI
small pancreatic islets / MGI
decreased trabecular bone thickness / MGI
abnormal endoplasmic reticulum morphology / MGI
abnormal aorta elastic tissue morphology / MGI
abnormal aorta tunica adventitia morphology / MGI
decreased total body fat amount / MGI
abnormal thoracic cage shape / MGI
decreased bone mineral content / MGI
abnormal heart electrocardiography waveform feature / MGI
myocardial hypertrophy / MGI
increased QRS amplitude / MGI
abnormal bone trabecula morphology / MGI
decreased bone trabecula number / MGI
decreased bone volume / MGI
decreased trabecular bone volume / MGI
pulmonary alveolar hemorrhage / MGI
abnormal compact bone lamellar structure / MGI
postnatal lethality, incomplete penetrance / MGI
neonatal lethality, complete penetrance / MGI
neonatal lethality, incomplete penetrance / MGI
prenatal lethality, complete penetrance / MGI
embryonic lethality, complete penetrance / MGI
embryonic lethality during organogenesis, complete penetrance / MGI
preweaning lethality, incomplete penetrance / MGI
abnormal bone collagen fibril morphology / MGI
abnormal tendon collagen fibril morphology / MGI
decreased neuronal stem cell self-renewal / MGI
thin body / MGI
abnormal extracellular matrix morphology / MGI
osteophytes / MGI
increased bone trabecular spacing / MGI
decreased bone trabecular spacing / MGI
decreased bone ossification / MGI
decreased bone mineralization / MGI
decreased collagen level / MGI
broad face / MGI
thick neurocranium / MGI
thin neurocranium / MGI
increased osteoblast apoptosis / MGI
abnormal dentin mineralization / MGI
increased osteocyte apoptosis / MGI
abnormal osteocyte lacuna morphology / MGI
joint contracture / MGI
atlanto-occipital joint dislocation / MGI
abnormal olecranon morphology / MGI
abnormal ear pigmentation / MGI
decreased circulating LDL cholesterol level / MGI
decreased hematocrit / MGI
increased leukocyte cell number / MGI
decreased neutrophil cell number / MGI
extramedullary hematopoiesis / MGI
abnormal erythropoiesis / MGI
abnormal myocardial fiber morphology / MGI
abnormal cell death / MGI
increased granulocyte number / MGI
increased cell proliferation / MGI
alopecia / MGI
short snout / MGI
abnormal digestive system morphology / MGI
gastrointestinal hemorrhage / MGI
increased rib number / MGI
abnormal pulmonary artery morphology / MGI
rectal prolapse / MGI
abnormal renal/urinary system morphology / MGI
abnormal mammary gland development / MGI
abnormal spleen morphology / MGI
enlarged spleen / MGI
enlarged lymph nodes / MGI
dystrophic muscle / MGI
absent notochord / MGI
abnormal retinal photoreceptor morphology / MGI
abnormal neuromuscular synapse morphology / MGI
pigmentation phenotype / MGI
increased body weight / MGI
decreased body weight / MGI
decreased body size / MGI
retinal degeneration / MGI
disorganized retinal layers / MGI
abnormal optic nerve morphology / MGI
decreased anxiety-related response / MGI
circling / MGI
hypoactivity / MGI
impaired coordination / MGI
abnormal eating behavior / MGI
limb grasping / MGI
increased circulating triglyceride level / MGI
increased circulating free fatty acid level / MGI
increased circulating HDL cholesterol level / MGI
hyperglycemia / MGI
anemia / MGI
abnormal blood vessel morphology / MGI
abnormal mesoderm development / MGI
abnormal somite development / MGI
decreased trophoblast giant cell number / MGI
postnatal growth retardation / MGI
impaired wound healing / MGI
abnormal humoral immune response / MGI
arrested B cell differentiation / MGI
arrested T cell differentiation / MGI
increased inflammatory response / MGI
reduced fertility / MGI
reduced female fertility / MGI
male infertility / MGI
decreased litter size / MGI
respiratory distress / MGI
abnormal pain threshold / MGI
increased thermal nociceptive threshold / MGI
abnormal coat/hair pigmentation / MGI
abnormal glucose homeostasis / MGI
increased circulating insulin level / MGI
premature death / MGI
abnormal tail morphology / MGI
abnormal kidney morphology / MGI
abnormal neural tube morphology / MGI
no abnormal phenotype detected / MGI
abnormal seminiferous tubule morphology / MGI
small lymph nodes / MGI
abnormal spleen white pulp morphology / MGI
abnormal bone marrow cell morphology/development / MGI
abnormal megakaryocyte progenitor cell morphology / MGI
abnormal proerythroblast morphology / MGI
abnormal megakaryocyte morphology / MGI
increased mean corpuscular volume / MGI
decreased mean corpuscular volume / MGI
increased mean platelet volume / MGI
hepatic steatosis / MGI
abnormal epididymis morphology / MGI
vestigial tail / MGI
reticulocytosis / MGI
abnormal keratinocyte differentiation / MGI
decreased circulating corticosterone level / MGI
asthenozoospermia / MGI
oligozoospermia / MGI
abnormal renal tubule morphology / MGI
decreased circulating insulin level / MGI
abnormal chemical nociception / MGI
dilated heart left ventricle / MGI
decreased vertical activity / MGI
abnormal notochord morphology / MGI
abnormal ocular fundus morphology / MGI
albuminuria / MGI
decreased hemoglobin content / MGI
decreased erythrocyte cell number / MGI
no phenotypic analysis / MGI
vertebral transformation / MGI
abnormal lumbar vertebrae morphology / MGI
abnormal skeletal muscle fiber morphology / MGI
absent allantois / MGI
hypospadia / MGI
anal atresia / MGI
increased erythroid progenitor cell number / MGI
abnormal embryonic hematopoiesis / MGI
kinked neural tube / MGI
epididymal inflammation / MGI
nervous system phenotype / MGI
abnormal nervous system morphology / MGI
kidney cysts / MGI
pallor / MGI
abnormal neural tube closure / MGI
abnormal retinal inner nuclear layer morphology / MGI
vascular smooth muscle hypoplasia / MGI
skeletal muscle necrosis / MGI
abnormal defecation / MGI
abnormal heart left ventricle morphology / MGI
abnormal circulating lipid level / MGI
abnormal hormone level / MGI
increased lean body mass / MGI
abnormal rod electrophysiology / MGI
abnormal cone electrophysiology / MGI
caudal body truncation / MGI
abnormal vitelline vascular remodeling / MGI
abnormal sarcomere morphology / MGI
increased compact bone thickness / MGI
transmission ratio distortion / MGI
abnormal basement membrane morphology / MGI
short frontal bone / MGI
short nasal bone / MGI
increased incidence of tumors by chemical induction / MGI
caudal vertebral transformation / MGI
cervical vertebral transformation / MGI
lumbar vertebral transformation / MGI
thoracic vertebral transformation / MGI
cervical vertebral fusion / MGI
absent caudal vertebrae / MGI
small sacral vertebrae / MGI
abnormal vertebral column morphology / MGI
notochord degeneration / MGI
truncated notochord / MGI
abnormal platelet morphology / MGI
decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
increased hematopoietic stem cell number / MGI
decreased testis weight / MGI
increased energy expenditure / MGI
decreased adiponectin level / MGI
decreased epididymis weight / MGI
abnormal epididymis epithelium morphology / MGI
skin inflammation / MGI
decreased B-1 B cell number / MGI
increased neuronal precursor cell number / MGI
increased osteoblast cell number / MGI
decreased lymphocyte cell number / MGI
decreased cardiac muscle contractility / MGI
cachexia / MGI
increased susceptibility to injury / MGI
decreased circulating cholesterol level / MGI
abnormal retinal pigment epithelium morphology / MGI
abnormal rostral-caudal axis patterning / MGI
glomerulosclerosis / MGI
increased oxygen consumption / MGI
impaired glucose tolerance / MGI
spina bifida occulta / MGI
decreased triglyceride level / MGI
abnormal renal glomerulus morphology / MGI
insulin resistance / MGI
muscle phenotype / MGI
homeostasis/metabolism phenotype / MGI
growth/size/body region phenotype / MGI
endocrine/exocrine gland phenotype / MGI
cardiovascular system phenotype / MGI
immune system phenotype / MGI
reproductive system phenotype / MGI
skeleton phenotype / MGI
hematopoietic system phenotype / MGI
increased circulating thyroxine level / MGI
increased circulating triiodothyronine level / MGI
abnormal skeleton morphology / MGI
abnormal body temperature / MGI
choroidal neovascularization / MGI
abnormal eye electrophysiology / MGI
decreased circulating glucose level / MGI
increased mean corpuscular hemoglobin / MGI
decreased mean corpuscular hemoglobin / MGI
decreased angiogenesis / MGI
increased bone mass / MGI
abnormal cell physiology / MGI
increased susceptibility to diet-induced obesity / MGI
decreased susceptibility to diet-induced obesity / MGI
decreased circulating leptin level / MGI
increased circulating leptin level / MGI
increased mitochondrial fission / MGI
increased apoptosis / MGI
abnormal tail development / MGI
abnormal spermatid morphology / MGI
intestine polyps / MGI
abnormal paraxial mesoderm morphology / MGI
abnormal podocyte slit diaphragm morphology / MGI
decreased CD4-positive, alpha beta T cell number / MGI
decreased CD8-positive, alpha-beta T cell number / MGI
abnormal granulocyte differentiation / MGI
abnormal monocyte differentiation / MGI
podocyte foot process effacement / MGI
increased germinal center B cell number / MGI
decreased B-2 B cell number / MGI
decreased mature B cell number / MGI
increased megakaryocyte cell number / MGI
abnormal bone ossification / MGI
retinal photoreceptor degeneration / MGI
abnormal medium spiny neuron morphology / MGI
retinal outer nuclear layer degeneration / MGI
increased circulating tumor necrosis factor level / MGI
increased circulating interleukin-1 alpha level / MGI
increased circulating interleukin-1 beta level / MGI
increased interleukin-17 secretion / MGI
decreased survivor rate / MGI
increased B cell apoptosis / MGI
increased liver iron level / MGI
increased spleen iron level / MGI
increased circulating iron level / MGI
lipofuscinosis / MGI
abnormal physiological response to xenobiotic / MGI
decreased erythroid progenitor cell number / MGI
anal stenosis / MGI
hairpin sperm flagellum / MGI
increased abdominal fat pad weight / MGI
increased trophoblast giant cell number / MGI
centrally nucleated skeletal muscle fibers / MGI
skeletal muscle endomysial fibrosis / MGI
abnormal synaptonemal complex / MGI
abnormal mammary gland duct morphology / MGI
decreased thymocyte apoptosis / MGI
enlarged popliteal lymph nodes / MGI
decreased birth body size / MGI
impaired somite development / MGI
increased total body fat amount / MGI
abnormal placenta physiology / MGI
abnormal retinal blood vessel morphology / MGI
decreased mammary gland epithelial cell proliferation / MGI
decreased tumor latency / MGI
altered tumor pathology / MGI
mortality/aging / MGI
integument phenotype / MGI
increased bone volume / MGI
abnormal double-strand DNA break repair / MGI
neonatal lethality, complete penetrance / MGI
perinatal lethality, incomplete penetrance / MGI
prenatal lethality, complete penetrance / MGI
embryonic lethality during organogenesis, complete penetrance / MGI
preweaning lethality, complete penetrance / MGI
prenatal lethality, incomplete penetrance / MGI
embryonic lethality during organogenesis, incomplete penetrance / MGI
abnormal anterior visceral endoderm cell migration / MGI
increased circulating erythropoietin level / MGI
renal tubule atrophy / MGI
lethality, complete penetrance / MGI
increased mitochondria number / MGI
rectal atresia / MGI
rectourethral fistula / MGI
increased hematopoietic stem cell proliferation / MGI
increased food intake / MGI
impaired mammary gland growth during pregnancy / MGI
decreased paraxial mesoderm size / MGI
abnormal skeletal muscle regeneration / MGI
testis degeneration / MGI
preputial gland inflammation / MGI
nervous system inclusion bodies / MGI
decreased fatty acid beta-oxidation / MGI
epididymis hypertrophy / MGI
spermatocele / MGI
epididymis fibrosis / MGI
increased epididymal cell proliferation / MGI
increased epididymal epithelium cell proliferation / MGI
increased heart iron level / MGI
increased intestinal iron level / MGI
abnormal intestine morphology / MGI
abnormal tibia morphology / MGI
decreased body size / MGI
abnormal cornea morphology / MGI
multifocal hepatic necrosis / MGI
abnormal T cell activation / MGI
decreased level of surface class I molecules / MGI
increased mammary adenocarcinoma incidence / MGI
no abnormal phenotype detected / MGI
increased susceptibility to bacterial infection / MGI
increased susceptibility to viral infection / MGI
abnormal leukocyte physiology / MGI
abnormal macrophage physiology / MGI
increased IgG level / MGI
increased myocardial infarction size / MGI
abnormal cell cycle / MGI
abnormal redox activity / MGI
increased cardiomyocyte apoptosis / MGI
abnormal nitric oxide homeostasis / MGI
increased compact bone thickness / MGI
decreased B-1 B cell number / MGI
increased osteoclast cell number / MGI
increased bone resorption / MGI
decreased B cell number / MGI
abnormal response to infection / MGI
abnormal MHC II cell surface expression on macrophages / MGI
impaired natural killer cell mediated cytotoxicity / MGI
immune system phenotype / MGI
vision/eye phenotype / MGI
abnormal T-helper 2 physiology / MGI
increased bone mass / MGI
abnormal cell physiology / MGI
abnormal common myeloid progenitor cell morphology / MGI
increased NK T cell number / MGI
decreased NK cell number / MGI
increased CD4-positive, alpha beta T cell number / MGI
decreased CD8-positive, alpha-beta T cell number / MGI
decreased single-positive T cell number / MGI
decreased susceptibility to neuronal excitotoxicity / MGI
abnormal osteoblast differentiation / MGI
abnormal osteoclast differentiation / MGI
decreased interferon-gamma secretion / MGI
increased circulating interferon-gamma level / MGI
decreased circulating interferon-gamma level / MGI
increased circulating interleukin-12b level / MGI
decreased interleukin-1 beta secretion / MGI
decreased susceptibility to endotoxin shock / MGI
decreased NK cell degranulation / MGI
decreased hepatocyte apoptosis / MGI
decreased sensitivity to induced cell death / MGI
increased susceptibility to bacterial infection induced morbidity/mortality / MGI
tumor regression / MGI
abnormal NK cell physiology / MGI
increased effector memory CD8-positive, alpha-beta T cell number / MGI
increased trabecular bone volume / MGI
increased compact bone volume / MGI
increased macrophage nitric oxide production / MGI
lethality at weaning, complete penetrance / MGI
abnormal CD8-positive, naive alpha-beta T cell number / MGI

Literature references

Inducible, dose-adjustable and time-restricted reconstitution of STAT1 deficiency in vivo.;Leitner Nicole R, Lassnig Caroline, Rom Rita, Heider Susanne, Bago-Horvath Zsuzsanna, Eferl Robert, Müller Simone, Kolbe Thomas, Kenner Lukas, Rülicke Thomas, Strobl Birgit, Müller Mathias, ;2014;PloS one;9;e86608; 24489749

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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B6N.Cg-Stat1tm1Dlv Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-Stat1)Biat/Biat