C57BL/6NTac-Alms1tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:09931
International strain nameC57BL/6NTac-Alms1tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0522_6_G08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAlms1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolAlms1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0522_6_G08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased circulating amylase level / IMPC
  • abnormal locomotor behavior / IMPC
MGI phenotypes (gene matching)
  • increased white adipose tissue amount / MGI
  • abnormal circulating cholesterol level / MGI
  • enlarged liver / MGI
  • abnormal hepatocyte morphology / MGI
  • small gonad / MGI
  • seminiferous tubule degeneration / MGI
  • abnormal spermatogenesis / MGI
  • increased body weight / MGI
  • obese / MGI
  • increased body size / MGI
  • retinal degeneration / MGI
  • increased circulating triglyceride level / MGI
  • increased circulating HDL cholesterol level / MGI
  • hyperglycemia / MGI
  • increased circulating insulin level / MGI
  • abnormal seminiferous tubule morphology / MGI
  • hepatic steatosis / MGI
  • dilated renal tubules / MGI
  • albuminuria / MGI
  • increased urine protein level / MGI
  • increased liver weight / MGI
  • enlarged kidney / MGI
  • liver fibrosis / MGI
  • abnormal retinal outer nuclear layer morphology / MGI
  • increased kidney weight / MGI
  • abnormal proximal convoluted tubule morphology / MGI
  • increased circulating cholesterol level / MGI
  • abnormal eye physiology / MGI
  • impaired glucose tolerance / MGI
  • insulin resistance / MGI
  • cellular phenotype / MGI
  • increased susceptibility to weight gain / MGI
  • pancreatic islet hyperplasia / MGI
  • retinal pigment epithelium atrophy / MGI
  • abnormal eye electrophysiology / MGI
  • increased circulating leptin level / MGI
  • increased fat cell size / MGI
  • impaired hearing / MGI
  • retinal photoreceptor degeneration / MGI
  • retinal outer nuclear layer degeneration / MGI
  • dilated proximal convoluted tubules / MGI
  • degranulated pancreatic beta cells / MGI
  • crystalluria / MGI
  • increased total body fat amount / MGI
  • abnormal renal tubule epithelial cell primary cilium morphology / MGI
  • increased kidney apoptosis / MGI
  • tubulointerstitial nephritis / MGI
  • increased kidney cell proliferation / MGI
  • increased food intake / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • increased fasted circulating glucose level / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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