MGI phenotypes (allele matching)
B6;129X1-Tcl1tm1Rso/Cnrm
| Status | Available to order |
| EMMA ID | EM:09917 |
| Citation information | RRID:IMSR_EM:09917 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129X1-Tcl1tm1Rso/Cnrm |
| Alternative name | Tcl1_KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tcl1tm1Rso |
| Gene/Transgene symbol | Tcl1 |
Information from provider
| Provider | Giandomenico Russo |
| Provider affiliation | oncologia molecolare, IDI-IRCCS |
| Genetic information | In-frame insertion of a PGK-neo cassette replaced sequences that code for exons 2, 3 and 4 of the Tcl1 gene. |
| Phenotypic information | Homozygous:Tcl1-/- mice have a modest impairment in the development and function of the immune system. Maternally derived Tcl1 is essential to early mouse embryo development, thus Tcl1-/- females show fertility defects, while Tcl1-/- males do not. Tcl1-/- adult mice (independently from sex) exhibit hair loss, leading to alopecia with extensive skin lesions.Heterozygous:Both males and females Tcl1+/- mice do not present any discernable defect. |
| Breeding history | The F1 animals were intercrossed for at least 20 generations. |
| References |
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| Homozygous fertile | males only |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- TCL1 participates in early embryonic development and is overexpressed in human seminomas.;Narducci Maria Grazia, Fiorenza Maria Teresa, Kang Sang-Moo, Bevilacqua Arturo, Di Giacomo Monica, Remotti Daniele, Picchio Maria Cristina, Fidanza Vincenzo, Cooper Max D, Croce Carlo Maria, Mangia Franco, Russo Giandomenico, ;2002;Proceedings of the National Academy of Sciences of the United States of America;99;11712-7; 12181493
- Impaired T- and B-cell development in Tcl1-deficient mice.;Kang Sang-Moo, Narducci Maria Grazia, Lazzeri Cristina, Mongiovì Adriana M, Caprini Elisabetta, Bresin Antonella, Martelli Fabio, Rothstein Jay, Croce Carlo Maria, Cooper Max D, Russo Giandomenico, ;2005;Blood;105;1288-94; 15479728
- TCL1 promotes blastomere proliferation through nuclear transfer, but not direct phosphorylation, of AKT/PKB in early mouse embryos.;Fiorenza M T, Torcia S, Canterini S, Bevilacqua A, Narducci M G, Ragone G, Croce C M, Russo G, Mangia F, ;2008;Cell death and differentiation;15;420-2; 17901877
- The Tcl1 oncogene defines secondary hair germ cells differentiation at catagen-telogen transition and affects stem-cell marker CD34 expression.;Ragone G, Bresin A, Piermarini F, Lazzeri C, Picchio M C, Remotti D, Kang S-M, Cooper M D, Croce C M, Narducci M G, Russo G, ;2009;Oncogene;28;1329-38; 19169282