IMPC phenotypes (gene matching)
B6.129P2-Tyk2tm1Mmul/Biat
| Status | Available to order |
| EMMA ID | EM:09904 |
| Citation information | RRID:IMSR_EM:09904 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Tyk2tm1Mmul/Biat |
| Alternative name | B6.129P2-Tyk2 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Tyk2tm1Mmul |
| Gene/Transgene symbol | Tyk2 |
Information from provider
| Provider | Mathias Müller |
| Provider affiliation | Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna |
| Additional owner | Prof. Thomas Rülicke, University of Veterinary Medicine, Institute of Laboratory Animal Science, Vienna, Austria |
| Genetic information | A loxP site was inserted upstream of exon 3. A floxed neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and left exon 3 floxed. (J:215350) |
| Phenotypic information | Homozygous:noneHeterozygous:none |
| Breeding history | Backcross via Speed Congenics |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | homozygous C57BL/6;129P2/OlaHsd males |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased body weight / MGI
- obese / MGI
- increased circulating free fatty acid level / MGI
- abnormal body temperature homeostasis / MGI
- decreased IgG level / MGI
- increased circulating insulin level / MGI
- abnormal T cell differentiation / MGI
- increased susceptibility to viral infection / MGI
- abnormal T cell physiology / MGI
- abnormal brown adipose tissue morphology / MGI
- abnormal cell cycle / MGI
- decreased susceptibility to induced arthritis / MGI
- abnormal nitric oxide homeostasis / MGI
- increased cholesterol level / MGI
- decreased energy expenditure / MGI
- abnormal response to infection / MGI
- increased susceptibility to parasitic infection / MGI
- impaired glucose tolerance / MGI
- abnormal T-helper 1 physiology / MGI
- abnormal mitochondrial physiology / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased interferon-gamma secretion / MGI
- increased circulating interleukin-12 level / MGI
- abnormal splenocyte physiology / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- impaired adaptive thermogenesis / MGI
- decreased macrophage nitric oxide production / MGI
- abnormal fat cell differentiation / MGI
- disorganized mitochondrial cristae / MGI
Literature references
- Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance.;Vielnascher Raimund M, Hainzl Eva, Leitner Nicole R, Rammerstorfer Michael, Popp David, Witalisz Agnieszka, Rom Rita, Karaghiosoff Marina, Kolbe Thomas, Müller Simone, Rülicke Thomas, Lassnig Caroline, Strobl Birgit, Müller Mathias, ;2014;Transgenic research;23;519-29; 24696087