IMPC phenotypes (gene matching)
B6.129P2-Tyk2tm1Mmul/Biat
| Status | Available to order |
| EMMA ID | EM:09904 |
| International strain name | B6.129P2-Tyk2tm1Mmul/Biat |
| Alternative name | B6.129P2-Tyk2 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Tyk2tm1Mmul |
| Gene/Transgene symbol | Tyk2 |
Information from provider
| Provider | Mathias Müller |
| Provider affiliation | Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna |
| Additional owner | Prof. Thomas Rülicke, University of Veterinary Medicine, Institute of Laboratory Animal Science, Vienna, Austria |
| Genetic information | A loxP site was inserted upstream of exon 3. A floxed neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and left exon 3 floxed. (J:215350) |
| Phenotypic information | Homozygous:noneHeterozygous:none |
| Breeding history | Backcross via Speed Congenics |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | homozygous C57BL/6;129P2/OlaHsd |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased body weight / MGI
- obese / MGI
- increased circulating free fatty acid level / MGI
- abnormal body temperature homeostasis / MGI
- decreased IgG level / MGI
- increased circulating insulin level / MGI
- abnormal T cell differentiation / MGI
- increased susceptibility to viral infection / MGI
- abnormal T cell physiology / MGI
- abnormal brown adipose tissue morphology / MGI
- abnormal cell cycle / MGI
- decreased susceptibility to induced arthritis / MGI
- abnormal nitric oxide homeostasis / MGI
- increased cholesterol level / MGI
- decreased energy expenditure / MGI
- abnormal response to infection / MGI
- increased susceptibility to parasitic infection / MGI
- impaired glucose tolerance / MGI
- abnormal T-helper 1 physiology / MGI
- abnormal mitochondrial physiology / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased interferon-gamma secretion / MGI
- increased circulating interleukin-12 level / MGI
- abnormal splenocyte physiology / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- impaired adaptive thermogenesis / MGI
- decreased macrophage nitric oxide production / MGI
- abnormal fat cell differentiation / MGI
- disorganized mitochondrial cristae / MGI
Literature references
- Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance.;Vielnascher Raimund M, Hainzl Eva, Leitner Nicole R, Rammerstorfer Michael, Popp David, Witalisz Agnieszka, Rom Rita, Karaghiosoff Marina, Kolbe Thomas, Müller Simone, Rülicke Thomas, Lassnig Caroline, Strobl Birgit, Müller Mathias, ;2014;Transgenic research;23;519-29; 24696087