IMPC phenotypes (gene matching)
B6.129P2-Tyk2tm1Biat/Biat
| Status | Available to order |
| EMMA ID | EM:09882 |
| Citation information | RRID:IMSR_EM:09882 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Tyk2tm1Biat/Biat |
| Alternative name | B6.129P2-Tyk2 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tyk2tm1Biat |
| Gene/Transgene symbol | Tyk2 |
Information from provider
| Provider | Mathias Müller |
| Provider affiliation | Department for Biomedical Sciences, Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna (Vetmeduni Vienna) |
| Additional owner | Prof. Thomas Rülicke, University of Veterinary Medicine, Institute of Laboratory Animal Science, Vienna, Austria |
| Genetic information | A neo cassette replaced most of the exons encoding the Jak homology (JH) domains JH7 (partly), JH6/5 and JH4 (partly). Western blot analysis confirmed the absence of protein expression in bone marrow macrophage. (J:65408) |
| Phenotypic information | Homozygous:immune deficiencyHeterozygous:not known |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Susceptibility to infection due to TYK2 deficiency / Orphanet_331226
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- increased body weight / MGI
- obese / MGI
- increased circulating free fatty acid level / MGI
- abnormal body temperature homeostasis / MGI
- decreased IgG level / MGI
- increased circulating insulin level / MGI
- abnormal T cell differentiation / MGI
- increased susceptibility to viral infection / MGI
- abnormal T cell physiology / MGI
- abnormal brown adipose tissue morphology / MGI
- abnormal cell cycle / MGI
- decreased susceptibility to induced arthritis / MGI
- abnormal nitric oxide homeostasis / MGI
- increased cholesterol level / MGI
- decreased energy expenditure / MGI
- abnormal response to infection / MGI
- increased susceptibility to parasitic infection / MGI
- impaired glucose tolerance / MGI
- abnormal T-helper 1 physiology / MGI
- abnormal mitochondrial physiology / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased interferon-gamma secretion / MGI
- increased circulating interleukin-12 level / MGI
- abnormal splenocyte physiology / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- impaired adaptive thermogenesis / MGI
- decreased macrophage nitric oxide production / MGI
- abnormal fat cell differentiation / MGI
- disorganized mitochondrial cristae / MGI
Literature references
- Partial impairment of cytokine responses in Tyk2-deficient mice.;Karaghiosoff M, Neubauer H, Lassnig C, Kovarik P, Schindler H, Pircher H, McCoy B, Bogdan C, Decker T, Brem G, Pfeffer K, Müller M, ;2000;Immunity;13;549-60; 11070173