IMPC phenotypes (gene matching)
B6.129P2-Tyk2tm1Biat/Biat
| Status | Available to order |
| EMMA ID | EM:09882 |
| International strain name | B6.129P2-Tyk2tm1Biat/Biat |
| Alternative name | B6.129P2-Tyk2 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tyk2tm1Biat |
| Gene/Transgene symbol | Tyk2 |
Information from provider
| Provider | Mathias Müller |
| Provider affiliation | Department for Biomedical Sciences, Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna (Vetmeduni Vienna) |
| Additional owner | Prof. Thomas Rülicke, University of Veterinary Medicine, Institute of Laboratory Animal Science, Vienna, Austria |
| Genetic information | A neo cassette replaced most of the exons encoding the Jak homology (JH) domains JH7 (partly), JH6/5 and JH4 (partly). Western blot analysis confirmed the absence of protein expression in bone marrow macrophage. (J:65408) |
| Phenotypic information | Homozygous:immune deficiencyHeterozygous:not known |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Susceptibility to infection due to TYK2 deficiency / Orphanet_331226
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- increased body weight / MGI
- obese / MGI
- increased circulating free fatty acid level / MGI
- abnormal body temperature homeostasis / MGI
- decreased IgG level / MGI
- increased circulating insulin level / MGI
- abnormal T cell differentiation / MGI
- increased susceptibility to viral infection / MGI
- abnormal T cell physiology / MGI
- abnormal brown adipose tissue morphology / MGI
- abnormal cell cycle / MGI
- decreased susceptibility to induced arthritis / MGI
- abnormal nitric oxide homeostasis / MGI
- increased cholesterol level / MGI
- decreased energy expenditure / MGI
- abnormal response to infection / MGI
- increased susceptibility to parasitic infection / MGI
- impaired glucose tolerance / MGI
- abnormal T-helper 1 physiology / MGI
- abnormal mitochondrial physiology / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased interferon-gamma secretion / MGI
- increased circulating interleukin-12 level / MGI
- abnormal splenocyte physiology / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- impaired adaptive thermogenesis / MGI
- decreased macrophage nitric oxide production / MGI
- abnormal fat cell differentiation / MGI
- disorganized mitochondrial cristae / MGI
Literature references
- Partial impairment of cytokine responses in Tyk2-deficient mice.;Karaghiosoff M, Neubauer H, Lassnig C, Kovarik P, Schindler H, Pircher H, McCoy B, Bogdan C, Decker T, Brem G, Pfeffer K, Müller M, ;2000;Immunity;13;549-60; 11070173