B6.129-Calb1tm1Mpin/JBiat

Status

Available to order

EMMA IDEM:09881
International strain nameB6.129-Calb1tm1Mpin/JBiat
Alternative nameB6.129-Calb1tm1Mpin
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCalb1tm1Mpin
Gene/Transgene symbolCalb1

Information from provider

ProviderMichael Meyer
Provider affiliationDepartment of Cellular Physiology, LMU München
Genetic informationTargeted Mutation (replacement of exon 1 of the Calbindin D28k gene by a targeting vector (PGK-promoter, neo-cassette).
Phenotypic informationHomozygous:
Mice homozygous for the Calb1 targeted mutation are viable and fertile. They show severe impairment in tests of motor coordination and exhibit ataxia when challenged on a runway. These results suggest functional deficits in cerebellar pathways. Confocal calcium imaging of cerebellar Purkinje cells reveals marked changes of synaptically-evoked postsynaptic calcium transients. No overt phenotype in normal cage environment.

Heterozygous:
not known (no overt phenotype in normal cage environment)
Breeding historyHistory before 2000 not known; since 2000 backcrossing to C57BL/6J, since 2011 to C57BL/6N.
References
  • Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene.;Airaksinen M S, Eilers J, Garaschuk O, Thoenen H, Konnerth A, Meyer M, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;1488-93; 9037080
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Animals used for archivinghomozygous C57BL/6N

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal thymus morphology / IMPC
  • abnormal vertebrae morphology / IMPC
  • abnormal testis morphology / IMPC
  • abnormal vertebral arch morphology / IMPC
  • hydrometra / IMPC
  • abnormal heart left ventricle morphology / IMPC
  • enlarged thymus / IMPC
  • small testis / IMPC
  • abnormal heart morphology / IMPC
  • enlarged heart / IMPC
  • abnormal spleen morphology / IMPC
  • small spleen / IMPC
  • enlarged spleen / IMPC
  • increased cardiac muscle contractility / IMPC
  • kyphosis / IMPC
  • abnormal retina morphology / IMPC
  • abnormal spine curvature / IMPC
  • abnormal uterus morphology / IMPC
MGI phenotypes (allele matching)
  • ataxia / MGI
  • abnormal nervous system electrophysiology / MGI
  • hearing/vestibular/ear phenotype / MGI
MGI phenotypes (gene matching)
  • ataxia / MGI
  • no abnormal phenotype detected / MGI
  • abnormal nervous system electrophysiology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • behavior/neurological phenotype / MGI

Literature references

  • Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene.;Airaksinen M S, Eilers J, Garaschuk O, Thoenen H, Konnerth A, Meyer M, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;1488-93; 9037080

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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