B6.129-Calb1tm1Mpin/JBiat

Status

Available to order

EMMA IDEM:09881
Citation informationRRID:IMSR_EM:09881 

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International strain nameB6.129-Calb1tm1Mpin/JBiat
Alternative nameB6.129-Calb1tm1Mpin
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCalb1tm1Mpin
Gene/Transgene symbolCalb1

Information from provider

ProviderMichael Meyer
Provider affiliationDepartment of Cellular Physiology, LMU München
Genetic informationTargeted Mutation (replacement of exon 1 of the Calbindin D28k gene by a targeting vector (PGK-promoter, neo-cassette).
Phenotypic informationHomozygous:
Mice homozygous for the Calb1 targeted mutation are viable and fertile. They show severe impairment in tests of motor coordination and exhibit ataxia when challenged on a runway. These results suggest functional deficits in cerebellar pathways. Confocal calcium imaging of cerebellar Purkinje cells reveals marked changes of synaptically-evoked postsynaptic calcium transients. No overt phenotype in normal cage environment.

Heterozygous:
not known (no overt phenotype in normal cage environment)
Breeding historyHistory before 2000 not known; since 2000 backcrossing to C57BL/6J, since 2011 to C57BL/6N.
References
  • Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene.;Airaksinen M S, Eilers J, Garaschuk O, Thoenen H, Konnerth A, Meyer M, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;1488-93; 9037080
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Animals used for archivinghomozygous C57BL/6N males

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal thymus morphology / IMPC
  • abnormal vertebrae morphology / IMPC
  • abnormal testis morphology / IMPC
  • abnormal vertebral arch morphology / IMPC
  • hydrometra / IMPC
  • abnormal heart left ventricle morphology / IMPC
  • enlarged thymus / IMPC
  • small testis / IMPC
  • abnormal heart morphology / IMPC
  • enlarged heart / IMPC
  • abnormal spleen morphology / IMPC
  • small spleen / IMPC
  • enlarged spleen / IMPC
  • increased cardiac muscle contractility / IMPC
  • kyphosis / IMPC
  • abnormal retina morphology / IMPC
  • abnormal spine curvature / IMPC
  • abnormal uterus morphology / IMPC
MGI phenotypes (allele matching)
  • ataxia / MGI
  • abnormal nervous system electrophysiology / MGI
  • hearing/vestibular/ear phenotype / MGI
MGI phenotypes (gene matching)
  • ataxia / MGI
  • no abnormal phenotype detected / MGI
  • abnormal nervous system electrophysiology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • behavior/neurological phenotype / MGI

Literature references

  • Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene.;Airaksinen M S, Eilers J, Garaschuk O, Thoenen H, Konnerth A, Meyer M, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;1488-93; 9037080

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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