C57BL/6N-Atm1Brd Tram2tm1a(KOMP)Wtsi/WtsiCnrm

Status

Available to order

EMMA IDEM:09847
International strain nameC57BL/6N-Atm1Brd Tram2tm1a(KOMP)Wtsi/WtsiCnrm
Alternative nameEPD0771_2_B12
Strain typeTargeted Mutant Strains
Allele/Transgene symbolTram2tm1a(KOMP)Wtsi
Gene/Transgene symbolTram2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0771_2_B12. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased bone mineral density / IMPC
  • abnormal scapula morphology / IMPC
  • kyphosis / IMPC
  • abnormal radius morphology / IMPC
  • abnormal joint morphology / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • abnormal spine curvature / IMPC
  • abnormal vertebral arch morphology / IMPC
  • abnormal ulna morphology / IMPC
  • abnormal humerus morphology / IMPC
  • decreased circulating serum albumin level / IMPC
  • decreased circulating total protein level / IMPC
  • absent pinna reflex / IMPC
  • increased circulating amylase level / IMPC
  • increased grip strength / IMPC
  • decreased bone mineral content / IMPC
IMPC phenotypes (gene matching)
  • abnormal humerus morphology / IMPC
  • decreased bone mineral content / IMPC
  • absent pinna reflex / IMPC
  • decreased circulating total protein level / IMPC
  • abnormal ulna morphology / IMPC
  • increased circulating amylase level / IMPC
  • decreased bone mineral density / IMPC
  • abnormal joint morphology / IMPC
  • decreased circulating serum albumin level / IMPC
  • kyphosis / IMPC
  • abnormal scapula morphology / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased grip strength / IMPC
  • abnormal radius morphology / IMPC
  • abnormal vertebral arch morphology / IMPC
  • abnormal spine curvature / IMPC

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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