MGI phenotypes (allele matching)
- decreased susceptibility to induced arthritis / MGI
FVB.129(Cg)-Bmxtm1Ali/Oulu
| Status | Available to order |
| EMMA ID | EM:09799 |
| International strain name | FVB.129(Cg)-Bmxtm1Ali/Oulu |
| Alternative name | Bmx KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Bmxtm1Ali |
| Gene/Transgene symbol | Bmx |
Information from provider
| Provider | Kari Alitalo |
| Provider affiliation | Research Programs Units, University of Helsinki |
| Genetic information | Deletion of the Bmx gene. |
| Phenotypic information | Homozygous:No obvious phenotype in unchallenged knock-out mice (Rajantie et al. 2001). Decreased tumor growth and tumor angiogenesis in several experimental tumor models (Holopainen et al. 2012).Heterozygous:In DMBA-TPA induced skin cancer model: no significant changes between Bmx+/0 and Bmx-/0 males. Increased tumor growth in Bmx+/- females but decreased tumor numbers in Bmx-/- females compared to Bmx+/+ females (Holopainen et al. 2012). |
| Breeding history | Original background DBA/2, backcrossed into C57BL/6 at least 8 times and further into FVB strain at least 5 times. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous FVB, wild-type FVB |
| Stage of embryos | 2-cell |
Disease and phenotype information
Literature references
- Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium.;Rajantie I, Ekman N, Iljin K, Arighi E, Gunji Y, Kaukonen J, Palotie A, Dewerchin M, Carmeliet P, Alitalo K, ;2001;Molecular and cellular biology;21;4647-55; 11416142
- Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth.;Holopainen Tanja, López-Alpuche Vanessa, Zheng Wei, Heljasvaara Ritva, Jones Dennis, He Yun, Tvorogov Denis, D'Amico Gabriela, Wiener Zoltan, Andersson Leif C, Pihlajaniemi Taina, Min Wang, Alitalo Kari, ;2012;Cancer research;72;3512-21; 22593188