C57BL/6NTac-Slc26a4tm2(EGFP/cre/ERT2)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:09769
International strain nameC57BL/6NTac-Slc26a4tm2(EGFP/cre/ERT2)Wtsi/WtsiH
Alternative nameCEPD0087_3_C07
Strain type
Allele/Transgene symbolSlc26a4tm2(EGFP/cre/ERT2)Wtsi
Gene/Transgene symbolSlc26a4

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone CEPD0087_3_C07. For further details on the construction of this clone see the page at the IMPC portal.
Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm2(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal inner ear morphology / MGI
  • abnormal cochlea morphology / MGI
  • abnormal inner ear vestibule morphology / MGI
  • abnormal organ of Corti morphology / MGI
  • organ of Corti degeneration / MGI
  • abnormal hair cell morphology / MGI
  • abnormal thyroid gland morphology / MGI
  • circling / MGI
  • bidirectional circling / MGI
  • impaired coordination / MGI
  • abnormal gait / MGI
  • head bobbing / MGI
  • impaired swimming / MGI
  • impaired balance / MGI
  • abnormal placing response / MGI
  • deafness / MGI
  • abnormal semicircular canal morphology / MGI
  • asthenozoospermia / MGI
  • oligozoospermia / MGI
  • abnormal otolith morphology / MGI
  • abnormal otolithic membrane morphology / MGI
  • absent otoliths / MGI
  • increased circulating bicarbonate level / MGI
  • enlarged otoliths / MGI
  • decreased otolith number / MGI
  • absent cochlear ganglion / MGI
  • decreased cochlear coiling / MGI
  • abnormal tectorial membrane morphology / MGI
  • abnormal scala media morphology / MGI
  • testicular atrophy / MGI
  • abnormal cochlear sensory epithelium morphology / MGI
  • abnormal calcium ion homeostasis / MGI
  • abnormal crista ampullaris morphology / MGI
  • abnormal spiral limbus morphology / MGI
  • enlarged vestibular saccule / MGI
  • vestibular hair cell degeneration / MGI
  • decreased vestibular hair cell number / MGI
  • vestibular saccular macula degeneration / MGI
  • utricular macular degeneration / MGI
  • cochlear hair cell degeneration / MGI
  • stria vascularis degeneration / MGI
  • thin stria vascularis / MGI
  • abnormal strial basal cell morphology / MGI
  • abnormal strial marginal cell morphology / MGI
  • abnormal strial intermediate cell morphology / MGI
  • cochlear inner hair cell degeneration / MGI
  • cochlear outer hair cell degeneration / MGI
  • absent cochlear hair cells / MGI
  • decreased cochlear hair cell number / MGI
  • absent endocochlear potential / MGI
  • decreased endocochlear potential / MGI
  • type I spiral ligament fibrocyte degeneration / MGI
  • type II spiral ligament fibrocyte degeneration / MGI
  • dilated cochlea / MGI
  • abnormal cochlear hair cell stereociliary bundle morphology / MGI
  • fused inner hair cell stereocilia / MGI
  • enlarged tectorial membrane / MGI
  • abnormal thyroid follicle morphology / MGI
  • sensorineural hearing loss / MGI
  • abnormal vestibular system physiology / MGI
  • nonsyndromic hearing loss / MGI
  • small scala tympani / MGI
  • thin spiral ligament / MGI
  • abnormal behavior / MGI
  • head tilt / MGI
  • head tossing / MGI
  • renal/urinary system phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • hearing/vestibular/ear phenotype / MGI
  • endocrine/exocrine gland phenotype / MGI
  • reproductive system phenotype / MGI
  • abnormal endolymphatic duct morphology / MGI
  • dilated endolymphatic duct / MGI
  • dilated endolymphatic sac / MGI
  • distended Reissner membrane / MGI
  • abnormal vestibular saccule morphology / MGI
  • abnormal utricle morphology / MGI
  • impaired hearing / MGI
  • absent pinna reflex / MGI
  • abnormal vestibular endolymph / MGI
  • abnormal vestibular endolymph ionic homeostasis / MGI
  • abnormal cochlear endolymph ionic homeostasis / MGI
  • dilated scala media / MGI
  • increased susceptibility to induced colitis / MGI
  • decreased urine pH / MGI
  • abnormal vestibular aqueduct morphology / MGI
  • decreased grip strength / MGI
  • increased urine ammonia level / MGI
  • increased or absent threshold for auditory brainstem response / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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