- abnormal inner ear morphology / MGI
- abnormal cochlea morphology / MGI
- abnormal inner ear vestibule morphology / MGI
- abnormal organ of Corti morphology / MGI
- organ of Corti degeneration / MGI
- abnormal hair cell morphology / MGI
- abnormal thyroid gland morphology / MGI
- circling / MGI
- bidirectional circling / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- head bobbing / MGI
- impaired swimming / MGI
- impaired balance / MGI
- abnormal placing response / MGI
- deafness / MGI
- abnormal semicircular canal morphology / MGI
- asthenozoospermia / MGI
- oligozoospermia / MGI
- abnormal otolith morphology / MGI
- abnormal otolithic membrane morphology / MGI
- absent otoliths / MGI
- increased circulating bicarbonate level / MGI
- enlarged otoliths / MGI
- decreased otolith number / MGI
- absent cochlear ganglion / MGI
- decreased cochlear coiling / MGI
- abnormal tectorial membrane morphology / MGI
- abnormal scala media morphology / MGI
- testicular atrophy / MGI
- abnormal cochlear sensory epithelium morphology / MGI
- abnormal calcium ion homeostasis / MGI
- abnormal crista ampullaris morphology / MGI
- abnormal spiral limbus morphology / MGI
- enlarged vestibular saccule / MGI
- vestibular hair cell degeneration / MGI
- decreased vestibular hair cell number / MGI
- vestibular saccular macula degeneration / MGI
- utricular macular degeneration / MGI
- cochlear hair cell degeneration / MGI
- stria vascularis degeneration / MGI
- thin stria vascularis / MGI
- abnormal strial basal cell morphology / MGI
- abnormal strial marginal cell morphology / MGI
- abnormal strial intermediate cell morphology / MGI
- cochlear inner hair cell degeneration / MGI
- cochlear outer hair cell degeneration / MGI
- absent cochlear hair cells / MGI
- decreased cochlear hair cell number / MGI
- absent endocochlear potential / MGI
- decreased endocochlear potential / MGI
- type I spiral ligament fibrocyte degeneration / MGI
- type II spiral ligament fibrocyte degeneration / MGI
- dilated cochlea / MGI
- abnormal cochlear hair cell stereociliary bundle morphology / MGI
- fused inner hair cell stereocilia / MGI
- enlarged tectorial membrane / MGI
- abnormal thyroid follicle morphology / MGI
- sensorineural hearing loss / MGI
- abnormal vestibular system physiology / MGI
- nonsyndromic hearing loss / MGI
- small scala tympani / MGI
- thin spiral ligament / MGI
- abnormal behavior / MGI
- head tilt / MGI
- head tossing / MGI
- renal/urinary system phenotype / MGI
- homeostasis/metabolism phenotype / MGI
- hearing/vestibular/ear phenotype / MGI
- endocrine/exocrine gland phenotype / MGI
- reproductive system phenotype / MGI
- abnormal endolymphatic duct morphology / MGI
- dilated endolymphatic duct / MGI
- dilated endolymphatic sac / MGI
- distended Reissner membrane / MGI
- abnormal vestibular saccule morphology / MGI
- abnormal utricle morphology / MGI
- impaired hearing / MGI
- absent pinna reflex / MGI
- abnormal vestibular endolymph / MGI
- abnormal vestibular endolymph ionic homeostasis / MGI
- abnormal cochlear endolymph ionic homeostasis / MGI
- dilated scala media / MGI
- increased susceptibility to induced colitis / MGI
- decreased urine pH / MGI
- abnormal vestibular aqueduct morphology / MGI
- decreased grip strength / MGI
- increased urine ammonia level / MGI
- increased or absent threshold for auditory brainstem response / MGI
C57BL/6NTac-Slc26a4tm2(EGFP/cre/ERT2)Wtsi/WtsiH
Status | Available to order |
EMMA ID | EM:09769 |
International strain name | C57BL/6NTac-Slc26a4tm2(EGFP/cre/ERT2)Wtsi/WtsiH |
Alternative name | CEPD0087_3_C07 |
Strain type | |
Allele/Transgene symbol | Slc26a4tm2(EGFP/cre/ERT2)Wtsi |
Gene/Transgene symbol | Slc26a4 |
Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from EUCOMM ES clone CEPD0087_3_C07. For further details on the construction of this clone see the page at the IMPC portal. Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm2(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Athyreosis / Orphanet_95713
- Thyroid hypoplasia / Orphanet_95720
- Autosomal recessive non-syndromic sensorineural deafness type DFNB / Orphanet_90636
- Pendred syndrome / Orphanet_705
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).