C57BL/6N-Atm1Brd Tial1tm1a(EUCOMM)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:09761
Citation informationRRID:IMSR_EM:09761 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Atm1Brd Tial1tm1a(EUCOMM)Wtsi/WtsiH
Alternative nameEPD0382_5_C09
Strain typeTargeted Mutant Strains
Allele/Transgene symbolTial1tm1a(EUCOMM)Wtsi
Gene/Transgene symbolTial1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0382_5_C09. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased lean body mass / IMPC
  • increased bone mineral density / IMPC
  • decreased total body fat amount / IMPC
  • thrombocytosis / IMPC
  • decreased circulating calcium level / IMPC
  • decreased circulating cholesterol level / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased circulating HDL cholesterol level / IMPC
MGI phenotypes (gene matching)
  • small ovary / MGI
  • ovary hyperplasia / MGI
  • small testis / MGI
  • decreased embryo size / MGI
  • postnatal growth retardation / MGI
  • male infertility / MGI
  • female infertility / MGI
  • absent ovarian follicles / MGI
  • decreased primordial germ cell number / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

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Practical information

Genotyping protocol

Example health report
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