B6N.Cg-Tg(Egr1-luc)5Ddl/Biat

Status	Available to order
EMMA ID	EM:09753
International strain name	B6N.Cg-Tg(Egr1-luc)5Ddl/Biat
Alternative name	B6N.Cg-Tg(Egr1-Luc)5Bnh/MMCT
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Egr1-Luc)5Bnh
Gene/Transgene symbol	Tg(Egr1-Luc)5Bnh

Information from provider

Provider	Elisabeth Deindl
Provider affiliation	Walter-Brendel-Center for Experimental Medicine , Ludwig-Maximilians-University
Additional owner	Submitted to EMMA by Prof. Manfred Ogris, University of Vienna, Vienna, Austria and Dr. Elisabeth Deindl, Ludwig-Maximilians-University, Munich, Germany
Genetic information	The firefly luciferase reporter gene is expressed under the control of the murine Early-growth-response-1 promoter (Egr1).
Phenotypic information	Homozygous: Firefly luciferase expression under the control of the murine Egr1 promoter (as active enzyme and on mRNA level) in embryonic, neonatal and regenerating tissue. Heterozygous: Firefly luciferase expression under the control of the murine Egr1 promoter (as active enzyme and on mRNA level) in embryonic, neonatal and regenerating tissue.
Breeding history	Animals were initially generated by microinjection of the Egr1-Luc reporter cassette into the male pronuclei of C57BL/6 and propagated for more than 6 generations in this strain. Thereafter animals were backcrossed into C57BL/6 albino mice obtained from Charles River (B6N-Tyr^c-Brd/BrdCrCrl) and maintained for more than 6 generations.
References	Live in vivo imaging of Egr-1 promoter activity during neonatal development, liver regeneration and wound healing.;Dussmann Philipp, Pagel Judith I, Vogel Sabina, Magnusson Terese, Zimmermann Rene, Wagner Ernst, Schaper Wolfgang, Ogris Manfred, Deindl Elisabeth, ;2011;BMC developmental biology;11;28; 21595990
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	University of Veterinary Medicine, Vienna, Austria
Animals used for archiving	heterozygous Other (please specify below)

Literature references

Live in vivo imaging of Egr-1 promoter activity during neonatal development, liver regeneration and wound healing.;Dussmann Philipp, Pagel Judith I, Vogel Sabina, Magnusson Terese, Zimmermann Rene, Wagner Ernst, Schaper Wolfgang, Ogris Manfred, Deindl Elisabeth, ;2011;BMC developmental biology;11;28; 21595990

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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