C57BL/6NTac-Vav1tm1(EGFP/cre/ERT2)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:09737
International strain nameC57BL/6NTac-Vav1tm1(EGFP/cre/ERT2)Wtsi/WtsiH
Alternative nameCEPD0077_3_B01
Strain type
Allele/Transgene symbolVav1tm1(EGFP/cre/ERT2)Wtsi
Gene/Transgene symbolVav1

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone CEPD0077_3_B01. For further details on the construction of this clone see the page at the IMPC portal.
Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (gene matching)
  • decreased thymocyte number / MGI
  • abnormal lymphocyte cell number / MGI
  • abnormal immune system physiology / MGI
  • abnormal humoral immune response / MGI
  • decreased IgG level / MGI
  • thymus hypoplasia / MGI
  • abnormal T cell activation / MGI
  • abnormal T cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal double-negative T cell morphology / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal T cell physiology / MGI
  • abnormal B cell number / MGI
  • decreased IgD level / MGI
  • increased IgM level / MGI
  • abnormal immune serum protein physiology / MGI
  • failure of blastocyst to hatch from the zona pellucida / MGI
  • transmission ratio distortion / MGI
  • abnormal CD8-positive, alpha-beta T cell physiology / MGI
  • abnormal negative T cell selection / MGI
  • abnormal positive T cell selection / MGI
  • decreased B-1 B cell number / MGI
  • increased T cell number / MGI
  • decreased T cell number / MGI
  • abnormal response to infection / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • decreased double-negative T cell number / MGI
  • increased double-negative T cell number / MGI
  • decreased double-positive T cell number / MGI
  • decreased B cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • immune system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • abnormal T cell number / MGI
  • decreased NK T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • abnormal CD4-positive T cell differentiation / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased single-positive T cell number / MGI
  • increased transitional stage B cell number / MGI
  • decreased mature B cell number / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased IgG3 level / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-gamma secretion / MGI
  • increased circulating interferon-gamma level / MGI
  • abnormal interleukin-2 secretion / MGI
  • decreased interleukin-2 secretion / MGI
  • decreased interleukin-4 secretion / MGI
  • abnormal splenic cell ratio / MGI
  • abnormal lymph node cell ratio / MGI
  • increased DN2 thymocyte number / MGI
  • increased DN3 thymocyte number / MGI
  • increased central memory CD4-positive, alpha-beta T cell number / MGI
  • increased effector memory CD4-positive, alpha-beta T cell number / MGI
  • increased central memory CD8 positive, alpha-beta T cell number / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI
  • decreased CD8-positive, naive alpha-beta T cell number / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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