B6.129P2-Aicdatm1.1(cre/ERT2)Crey/Ph

Status

Available to order

EMMA IDEM:09712
Citation informationRRID:IMSR_EM:09712 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129P2-Aicdatm1.1(cre/ERT2)Crey/Ph
Alternative nameAICDA-Cre-ERT2
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolAicdatm1.1(cre/ERT2)Crey
Gene/Transgene symbolAicda

Information from provider

ProviderClaude-Agnès Reynaud
Provider affiliationINSERM U1151/CNRS UMR 8253, Institut Necker-Enfants Malades
Genetic informationKnockin of a tamoxifen-inducible form of Cre recombinase at the AICDA locus.
Phenotypic informationHomozygous:
Immunodeficiency due to inactivation of the AICDA gene through targeted Cre-ERT2 insertion.

Heterozygous:
No obvious phenotype
Breeding history10 backcrosses to C57BL/6
References
  • Multiple layers of B cell memory with different effector functions.;Dogan Ismail, Bertocci Barbara, Vilmont Valérie, Delbos Frédéric, Mégret Jérome, Storck Sébastien, Reynaud Claude-Agnès, Weill Jean-Claude, ;2009;Nature immunology;10;1292-9; 19855380
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedyes

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic
Animals used for archivingheterozygous C57BL/6N males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased leukocyte cell number / IMPC
  • increased mean corpuscular hemoglobin concentration / IMPC
  • increased early germinal center B cell number / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • decreased late germinal center B cell number / IMPC
  • increased germinal center B cell number / IMPC
  • decreased follicular B cell number / IMPC
MGI phenotypes (gene matching)
  • abnormal humoral immune response / MGI
  • decreased IgG level / MGI
  • decreased IgA level / MGI
  • no abnormal phenotype detected / MGI
  • increased susceptibility to bacterial infection / MGI
  • decreased IgE level / MGI
  • increased IgM level / MGI
  • no phenotypic analysis / MGI
  • abnormal somatic hypermutation frequency / MGI
  • abnormal class switch recombination / MGI
  • immune system phenotype / MGI
  • increased germinal center B cell number / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
  • chromosomal instability / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • abnormal gut flora balance / MGI

Literature references

  • Multiple layers of B cell memory with different effector functions.;Dogan Ismail, Bertocci Barbara, Vilmont Valérie, Delbos Frédéric, Mégret Jérome, Storck Sébastien, Reynaud Claude-Agnès, Weill Jean-Claude, ;2009;Nature immunology;10;1292-9; 19855380

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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