C57BL/6NTac-Gmdstm1a(KOMP)Wtsi/WtsiIeg

Status

Available to order

EMMA IDEM:09706
International strain nameC57BL/6NTac-Gmdstm1a(KOMP)Wtsi/WtsiIeg
Alternative nameEPD0034_5_H06
Strain typeTargeted Mutant Strains
Allele/Transgene symbolGmdstm1a(KOMP)Wtsi
Gene/Transgene symbolGmds
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0034_5_H06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased hematocrit / IMPC
  • increased leukocyte cell number / IMPC
  • increased neutrophil cell number / IMPC
  • increased monocyte cell number / IMPC
  • increased granulocyte number / IMPC
  • abnormal cranium morphology / IMPC
  • abnormal snout morphology / IMPC
  • decreased body length / IMPC
  • decreased hemoglobin content / IMPC
  • decreased erythrocyte cell number / IMPC
  • abnormal bone structure / IMPC
  • decreased macrophage cell number / IMPC
  • decreased lean body mass / IMPC
  • decreased regulatory T cell number / IMPC
  • increased NK T cell number / IMPC
  • decreased NK cell number / IMPC
  • increased CD4-positive, alpha-beta T cell number / IMPC
  • decreased CD4-positive, alpha-beta T cell number / IMPC
  • increased CD8-positive, alpha-beta T cell number / IMPC
  • decreased CD8-positive, alpha-beta T cell number / IMPC
  • decreased plasmacytoid dendritic cell number / IMPC
  • decreased dendritic cell number / IMPC
  • increased gamma-delta T cell number / IMPC
  • increased circulating iron level / IMPC
  • decreased transitional stage T2 B cell number / IMPC
  • increased total body fat amount / IMPC
  • increased grip strength / IMPC
  • decreased circulating magnesium level / IMPC
  • decreased bone mineral content / IMPC
  • decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • decreased alpha-beta T cell number / IMPC
  • decreased KLRG1-positive NK cell number / IMPC
  • decreased KLRG1+ CD8 alpha-beta T cell number / IMPC
  • increased memory-marker NK cell number / IMPC
  • decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • decreased CD8-positive, naive alpha-beta T cell number / IMPC
  • increased CD4-negative NK T cell number / IMPC
  • decreased memory-marker CD4-negative NK T cell number / IMPC
  • decreased CD4-positive NK T cell number / IMPC
  • decreased memory-marker CD4-positive NK T cell number / IMPC
  • increased immature NK cell number / IMPC
  • decreased mature NK cell number / IMPC
  • decreased Ly6C-positive mature NK cell number / IMPC
  • increased Ly6C-positive NK T cell number / IMPC
  • decreased T-helper cell number / IMPC
IMPC phenotypes (gene matching)
  • increased leukocyte cell number / IMPC
  • decreased circulating magnesium level / IMPC
  • decreased CD8-positive, naive alpha-beta T cell number / IMPC
  • decreased CD4-positive NK T cell number / IMPC
  • decreased T-helper cell number / IMPC
  • decreased plasmacytoid dendritic cell number / IMPC
  • decreased CD4-positive, alpha-beta T cell number / IMPC
  • decreased NK cell number / IMPC
  • decreased body length / IMPC
  • increased NK T cell number / IMPC
  • decreased KLRG1-positive NK cell number / IMPC
  • decreased dendritic cell number / IMPC
  • decreased bone mineral content / IMPC
  • increased CD4-positive, alpha-beta T cell number / IMPC
  • increased CD4-negative NK T cell number / IMPC
  • increased neutrophil cell number / IMPC
  • increased gamma-delta T cell number / IMPC
  • decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • decreased regulatory T cell number / IMPC
  • decreased alpha-beta T cell number / IMPC
  • decreased mature NK cell number / IMPC
  • decreased CD8-positive, alpha-beta T cell number / IMPC
  • decreased KLRG1+ CD8 alpha-beta T cell number / IMPC
  • decreased transitional stage T2 B cell number / IMPC
  • abnormal bone structure / IMPC
  • decreased hemoglobin content / IMPC
  • decreased memory-marker CD4-negative NK T cell number / IMPC
  • decreased macrophage cell number / IMPC
  • increased memory-marker NK cell number / IMPC
  • decreased erythrocyte cell number / IMPC
  • decreased Ly6C-positive mature NK cell number / IMPC
  • increased total body fat amount / IMPC
  • increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • increased CD8-positive, alpha-beta T cell number / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • decreased memory-marker CD4-positive NK T cell number / IMPC
  • increased Ly6C-positive NK T cell number / IMPC
  • decreased hematocrit / IMPC
  • abnormal snout morphology / IMPC
  • increased circulating iron level / IMPC
  • increased granulocyte number / IMPC
  • decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • increased grip strength / IMPC
  • increased monocyte cell number / IMPC
  • increased immature NK cell number / IMPC
  • decreased lean body mass / IMPC
  • abnormal cranium morphology / IMPC

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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