C57BL/6N-Atm1Brd Celf4tm1a(EUCOMM)Wtsi/WtsiPh

Status

Available to order

EMMA IDEM:09705
International strain nameC57BL/6N-Atm1Brd Celf4tm1a(EUCOMM)Wtsi/WtsiPh
Alternative nameEPD0372_2_D05
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCelf4tm1a(EUCOMM)Wtsi
Gene/Transgene symbolCelf4
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0372_2_D05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased circulating calcium level / IMPC
  • increased circulating insulin level / IMPC
  • decreased circulating cholesterol level / IMPC
  • impaired glucose tolerance / IMPC
  • preweaning lethality, complete penetrance / IMPC
IMPC phenotypes (gene matching)
  • impaired glucose tolerance / IMPC
  • decreased circulating cholesterol level / IMPC
  • increased circulating insulin level / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • decreased circulating calcium level / IMPC
MGI phenotypes (allele matching)
  • abnormal bile duct morphology / MGI
  • abnormal eye muscle morphology / MGI
  • fetal growth retardation / MGI
  • dual inferior vena cava / MGI
  • abnormal ductus venosus valve morphology / MGI
  • blood in lymph vessels / MGI
  • abnormal vitelline vein topology / MGI
  • absent basilar artery segment / MGI
MGI phenotypes (gene matching)
  • increased body weight / MGI
  • decreased body size / MGI
  • hyperactivity / MGI
  • abnormal seizure response to electrical stimulation / MGI
  • seizures / MGI
  • premature death / MGI
  • no abnormal phenotype detected / MGI
  • abnormal bile duct morphology / MGI
  • absence seizures / MGI
  • abnormal eye muscle morphology / MGI
  • tonic-clonic seizures / MGI
  • fetal growth retardation / MGI
  • abnormal miniature excitatory postsynaptic currents / MGI
  • increased susceptibility to weight gain / MGI
  • abnormal spike wave discharge / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • dual inferior vena cava / MGI
  • abnormal ductus venosus valve morphology / MGI
  • blood in lymph vessels / MGI
  • abnormal vitelline vein topology / MGI
  • absent basilar artery segment / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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