C57BL/6NTac-Atp11a^{tm1e(KOMP)Wtsi}/WtsiIeg

Status	Available to order
EMMA ID	EM:09703
Citation information	RRID:IMSR_EM:09703 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NTac-Atp11a^{tm1e(KOMP)Wtsi}/WtsiIeg
Alternative name	EPD0111_4_B04
Strain type	Targeted Mutant Strains : Targeted Non-conditional
Allele/Transgene symbol	Atp11a^{tm1e(KOMP)Wtsi}
Gene/Transgene symbol	Atp11a
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0111_4_B04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

IMPC phenotypes (allele matching)

increased bone mineral density / IMPC
decreased circulating HDL cholesterol level / IMPC
increased leukocyte cell number / IMPC
abnormal retina morphology / IMPC
decreased circulating cholesterol level / IMPC
preweaning lethality, complete penetrance / IMPC

IMPC phenotypes (gene matching)

abnormal retina morphology / IMPC
preweaning lethality, complete penetrance / IMPC
increased leukocyte cell number / IMPC
increased bone mineral density / IMPC
decreased circulating HDL cholesterol level / IMPC
decreased circulating cholesterol level / IMPC

MGI phenotypes (gene matching)

overriding aortic valve / MGI
increased rib number / MGI
liver hypoplasia / MGI
enlarged liver sinusoidal spaces / MGI
abnormal thymus morphology / MGI
abnormal olfactory bulb morphology / MGI
exencephaly / MGI
small superior cervical ganglion / MGI
abnormal eye morphology / MGI
abnormal artery morphology / MGI
abnormal nasal cavity morphology / MGI
abnormal larynx morphology / MGI
aphakia / MGI
aorta coarctation / MGI
abnormal eye muscle morphology / MGI
abnormal Mullerian duct morphology / MGI
thin myocardium compact layer / MGI
abnormal adenohypophysis morphology / MGI
abnormal carotid artery morphology / MGI
abnormal optic stalk morphology / MGI
abnormal optic cup morphology / MGI
abnormal olfactory nerve morphology / MGI
narrow eye opening / MGI
abnormal Meckel's cartilage morphology / MGI
perimembraneous ventricular septal defect / MGI
muscular ventricular septal defect / MGI
herniated liver / MGI
abnormal vertebral artery morphology / MGI
umbilical vein stenosis / MGI
absent pectinate muscle / MGI
absent olfactory nerve / MGI
subcutaneous edema / MGI
trigeminal neuroma / MGI
absent ductus venosus valve / MGI
abnormal elbow joint morphology / MGI
multiple persisting craniopharyngeal ducts / MGI
reduced sympathetic cervical ganglion size / MGI
abnormal coronary sinus connection / MGI
abnormal umbilical vein topology / MGI
abnormal vitelline vein topology / MGI
additional anastomosis between intracranial vertebral arteries / MGI
heterochrony / MGI
persistent trigeminal artery / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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