B6NCrl;B6N-Atm1Brd Ddr1tm1a(EUCOMM)Hmgu/Orl

Status

Available to order

EMMA IDEM:09692
International strain nameB6NCrl;B6N-Atm1Brd Ddr1tm1a(EUCOMM)Hmgu/Orl
Alternative nameHEPD0812_6_B12
Strain typeTargeted Mutant Strains
Allele/Transgene symbolDdr1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolDdr1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Institut de Transgenose, INTRAGENE
Provider affiliationTAAM-CDTA UPS44, Institut de Transgenose, INTRAGENE
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0812_6_B12. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NCrl

Disease and phenotype information

IMPC phenotypes (gene matching)
  • hyperactivity / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
MGI phenotypes (gene matching)
  • abnormal cranium morphology / MGI
  • abnormal mammary gland development / MGI
  • decreased anxiety-related response / MGI
  • hyperactivity / MGI
  • failure of embryo implantation / MGI
  • postnatal growth retardation / MGI
  • abnormal lactation / MGI
  • abnormal outer ear morphology / MGI
  • abnormal bone mineralization / MGI
  • increased urine protein level / MGI
  • renal/urinary system phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • abnormal podocyte slit diaphragm morphology / MGI
  • abnormal mammary gland duct morphology / MGI
  • abnormal renal tubule epithelium morphology / MGI
  • increased mammary gland epithelial cell proliferation / MGI
  • increased renal glomerulus basement membrane thickness / MGI
  • erythrocyturia / MGI
  • abnormal aorta collagen fibril morphology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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