B6NTac;B6N-Atm1Brd Il31ratm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:09660
Citation informationRRID:IMSR_EM:09660 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6NTac;B6N-Atm1Brd Il31ratm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0673_5_F03
Strain typeTargeted Mutant Strains
Allele/Transgene symbolIl31ratm1a(EUCOMM)Hmgu
Gene/Transgene symbolIl31ra
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0673_5_F03. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased total body fat amount / IMPC
  • decreased bone mineral content / IMPC
  • decreased lean body mass / IMPC
MGI phenotypes (gene matching)
  • decreased bone marrow cell number / MGI
  • spleen hypoplasia / MGI
  • abnormal bone marrow cell morphology/development / MGI
  • abnormal macrophage physiology / MGI
  • increased IgE level / MGI
  • granulomatous inflammation / MGI
  • increased susceptibility to parasitic infection / MGI
  • increased T cell proliferation / MGI
  • immune system phenotype / MGI
  • abnormal common myeloid progenitor cell morphology / MGI
  • abnormal interleukin level / MGI

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Availabilities

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Practical information

Genotyping protocol

Example health report
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