IMPC phenotypes (gene matching)
B6;129P2-Anxa6tm1Moss/H
| Status | Available to order |
| EMMA ID | EM:09630 |
| Citation information | RRID:IMSR_EM:09630 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Anxa6tm1Moss/H |
| Alternative name | B6;129-Anxa6tm1SM |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Anxa6tm1Moss |
| Gene/Transgene symbol | Anxa6 |
Information from provider
| Provider | Stephen Moss |
| Provider affiliation | Cell Biology, UCL Institute of Ophthalmology |
| Genetic information | Insertion of neo-pa gene into exon 3 of annexin A6 gene. |
| Phenotypic information | Homozygous:Altered mechanical and intracellular calcium signalling in cardiomyocytes. Displays altered regulation of mitochondrial morphogenesis.Heterozygous:Not studied. |
| Breeding history | Inbred since 1999. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- Immunological development and cardiovascular function are normal in annexin VI null mutant mice.;Hawkins T E, Roes J, Rees D, Monkhouse J, Moss S E, ;1999;Molecular and cellular biology;19;8028-32; 10567528
- Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice.;Song Guojie, Harding Sian E, Duchen Michael R, Tunwell Richard, O'Gara Peter, Hawkins Tim E, Moss Stephen E, ;2002;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;16;622-4; 11919174
- Deficiency of annexins A5 and A6 induces complex changes in the transcriptome of growth plate cartilage but does not inhibit the induction of mineralization.;Belluoccio Daniele, Grskovic Ivan, Niehoff Anja, Schlötzer-Schrehardt Ursula, Rosenbaum Sabrina, Etich Julia, Frie Christian, Pausch Friedericke, Moss Stephen E, Pöschl Ernst, Bateman John F, Brachvogel Bent, ;2010;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;25;141-53; 19580468
- Intracellular modulation of signaling pathways by annexin A6 regulates terminal differentiation of chondrocytes.;Minashima Takeshi, Small William, Moss Stephen E, Kirsch Thorsten, ;2012;The Journal of biological chemistry;287;14803-15; 22399299
- Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle-mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response.;Grskovic Ivan, Kutsch Anna, Frie Christian, Groma Gergely, Stermann Jacek, Schlötzer-Schrehardt Ursula, Niehoff Anja, Moss Stephen E, Rosenbaum Sabrina, Pöschl Ernst, Chmielewski Markus, Rappl Gunter, Abken Hinrich, Bateman John F, Cheah Kathryn Se, Paulsson Mats, Brachvogel Bent, ;2012;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;27;2399-412; 22692895
- Regulation of mitochondrial morphogenesis by annexin A6.;Chlystun Marcin, Campanella Michelangelo, Law Ah-Lai, Duchen Michael R, Fatimathas Lux, Levine Tim P, Gerke Volker, Moss Stephen E, ;2013;PloS one;8;e53774; 23341998