IMPC phenotypes (allele matching)
C57BL/6N-Tfap2btm1b(EUCOMM)Wtsi/Ieg
| Status | Available to order |
| EMMA ID | EM:09626 |
| International strain name | C57BL/6N-Tfap2btm1b(EUCOMM)Wtsi/Ieg |
| Alternative name | EPD0764_4_A09 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Tfap2btm1b(EUCOMM)Wtsi |
| Gene/Transgene symbol | Tfap2b |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0764_4_A09. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (Gt(ROSA)26Sor |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6NTac |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Char syndrome / Orphanet_46627
- Familial patent arterial duct / Orphanet_466729
MGI phenotypes (gene matching)
- decreased circulating calcium level / MGI
- polydactyly / MGI
- muscle spasm / MGI
- tremors / MGI
- scaly skin / MGI
- increased circulating phosphate level / MGI
- postnatal growth retardation / MGI
- abnormal ion homeostasis / MGI
- abnormal kidney physiology / MGI
- increased circulating parathyroid hormone level / MGI
- decreased urine calcium level / MGI
- decreased urine osmolality / MGI
- small kidney / MGI
- patent ductus arteriosus / MGI
- kidney cysts / MGI
- increased renal tubule apoptosis / MGI
- increased circulating creatinine level / MGI
- increased blood urea nitrogen level / MGI
- congestive heart failure / MGI
- dilated proximal convoluted tubules / MGI
- postaxial polydactyly / MGI
- pulmonary vascular congestion / MGI
- abnormal pulmonary alveolar system morphology / MGI
- postnatal lethality, complete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- increased kidney apoptosis / MGI