IMPC phenotypes (gene matching)
- preweaning lethality, complete penetrance / IMPC
B6.129-Slc17a6tm1Kldr/Kctt
| Status | Available to order |
| EMMA ID | EM:09588 |
| Citation information | RRID:IMSR_EM:09588 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Slc17a6tm1Kldr/Kctt |
| Alternative name | VGLUT2-Lox-C57Bl/6-Backcross |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Slc17a6tm1Kldr |
| Gene/Transgene symbol | Slc17a6 |
Information from provider
| Provider | Åsa Mackenzie |
| Provider affiliation | Inst. för Neurovetenskap |
| Genetic information | The Slc17a6 (Vglut2) gene is flanked by loxP sites. |
| Phenotypic information | Homozygous:The mice have no known phenotype.Heterozygous:The mice have no known phenotype |
| Breeding history | The Vglut2-lox mouse has been generated on a mixed background, C57BL/6 and 129/Sv, and then been bred to a pure C57BL/6 background by performing 10 backcrosses to C57BL/6. The C57BL/6-backcrossed line was archived in EMMA. Published data refers to the mixed genetic background. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous C57BL/6J males |
Disease and phenotype information
MGI phenotypes (gene matching)
- hunched posture / MGI
- cyanosis / MGI
- respiratory failure / MGI
- abnormal reflex / MGI
- abnormal pain threshold / MGI
- abnormal motor capabilities/coordination/movement / MGI
- no abnormal phenotype detected / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal conditioned taste aversion behavior / MGI
- abnormal excitatory postsynaptic currents / MGI
- no phenotypic analysis / MGI
- abnormal locomotor activation / MGI
- abnormal nervous system physiology / MGI
- abnormal synaptic vesicle morphology / MGI
- abnormal synaptic vesicle number / MGI
- enlarged third ventricle / MGI
- decreased fetal weight / MGI
- decreased birth body size / MGI
- abnormal pre-Botzinger complex physiology / MGI
- absence of AMPA-mediated synaptic currents / MGI
- postnatal lethality, complete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
Literature references
- Vesicular glutamate transporter 2 is required for central respiratory rhythm generation but not for locomotor central pattern generation.;Wallén-Mackenzie Asa, Gezelius Henrik, Thoby-Brisson Muriel, Nygård Anna, Enjin Anders, Fujiyama Fumino, Fortin Gilles, Kullander Klas, ;2006;The Journal of neuroscience : the official journal of the Society for Neuroscience;26;12294-307; 17122055
- Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function.;Wallén-Mackenzie Asa, Nordenankar Karin, Fejgin Kim, Lagerström Malin C, Emilsson Lina, Fredriksson Robert, Wass Caroline, Andersson Daniel, Egecioglu Emil, Andersson My, Strandberg Joakim, Lindhe Orjan, Schiöth Helgi B, Chergui Karima, Hanse Eric, Långström Bengt, Fredriksson Anders, Svensson Lennart, Roman Erika, Kullander Klas, ;2009;The Journal of neuroscience : the official journal of the Society for Neuroscience;29;2238-51; 19228977
- VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation.;Birgner Carolina, Nordenankar Karin, Lundblad Martin, Mendez José Alfredo, Smith Casey, le Grevès Madeleine, Galter Dagmar, Olson Lars, Fredriksson Anders, Trudeau Louis-Eric, Kullander Klas, Wallén-Mackenzie Asa, ;2010;Proceedings of the National Academy of Sciences of the United States of America;107;389-94; 20018672
- A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain.;Lagerström Malin C, Rogoz Katarzyna, Abrahamsen Bjarke, Lind Anne-Li, Olund Caroline, Smith Casey, Mendez José Alfredo, Wallén-Mackenzie Åsa, Wood John N, Kullander Klas, ;2011;Proceedings of the National Academy of Sciences of the United States of America;108;5789-94; 21415372
- VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.;Lagerström Malin C, Rogoz Katarzyna, Abrahamsen Bjarke, Persson Emma, Reinius Björn, Nordenankar Karin, Olund Caroline, Smith Casey, Mendez José Alfredo, Chen Zhou-Feng, Wood John N, Wallén-Mackenzie Asa, Kullander Klas, ;2010;Neuron;68;529-42; 21040852
- Enhanced sucrose and cocaine self-administration and cue-induced drug seeking after loss of VGLUT2 in midbrain dopamine neurons in mice.;Alsiö Johan, Nordenankar Karin, Arvidsson Emma, Birgner Carolina, Mahmoudi Souha, Halbout Briac, Smith Casey, Fortin Guillaume M, Olson Lars, Descarries Laurent, Trudeau Louis-Éric, Kullander Klas, Lévesque Daniel, Wallén-Mackenzie Asa, ;2011;The Journal of neuroscience : the official journal of the Society for Neuroscience;31;12593-603; 21880920
- Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion.;Schweizer Nadine, Pupe Stéfano, Arvidsson Emma, Nordenankar Karin, Smith-Anttila Casey J A, Mahmoudi Souha, Andrén Anna, Dumas Sylvie, Rajagopalan Aparna, Lévesque Daniel, Leão Richardson N, Wallén-Mackenzie Åsa, ;2014;Proceedings of the National Academy of Sciences of the United States of America;111;7837-42; 24821804
- Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity.;Nordenankar Karin, Smith-Anttila Casey J A, Schweizer Nadine, Viereckel Thomas, Birgner Carolina, Mejia-Toiber Jana, Morales Marisela, Leao Richardson N, Wallén-Mackenzie Åsa, ;2015;Brain structure & function;220;2171-90; 24802380