B6D2-Tg(KRT14-Pgf)1Odo/Cnrm
| Status | Available to order |
| EMMA ID | EM:09586 |
| Citation information | RRID:IMSR_EM:09586 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6D2-Tg(KRT14-Pgf)1Odo/Cnrm |
| Alternative name | K14-PlGF |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(KRT14-Pgf)1Odo |
| Gene/Transgene symbol | Tg(KRT14-Pgf)1Odo |
Information from provider
| Provider | Teresa ODORISIO |
| Provider affiliation | Lab. Biologia Molecolare e Cellulare, Istituto Dermopatico dell'Immacolata |
| Genetic information | Transgenic mice overexpressing the full coding sequence of mouse placenta growth factor (PlGF) under the control of human keratin 14 promoter . |
| Phenotypic information | Homozygous:Homozygous mice were never obtained by crossing heterozygous mice.Heterozygous:Heterozygous transgenic mice manifest a strong increase in the number, branching and size of dermal blood vessels as well as enhanced vascular permeability. |
| Breeding history | For generating transgenic mice, fertilized oocytes were obtained from a (C57BL/6 x DBA/2) mouse cross. Transgenic lines were established on a B6D2F1 background, by crossing heterozygous mice (Tg/+) with B6D2F1 wt mice. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability.;Odorisio Teresa, Schietroma Cataldo, Zaccaria M Letizia, Cianfarani Francesca, Tiveron Cecilia, Tatangelo Laura, Failla Cristina M, Zambruno Giovanna, ;2002;Journal of cell science;115;2559-67; 12045226
- Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential.;Cianfarani Francesca, Zambruno Giovanna, Brogelli Laura, Sera Francesco, Lacal Pedro Miguel, Pesce Maurizio, Capogrossi Maurizio C, Failla Cristina Maria, Napolitano Monica, Odorisio Teresa, ;2006;The American journal of pathology;169;1167-82; 17003476
- Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.;Wirzenius Maria, Tammela Tuomas, Uutela Marko, He Yulong, Odorisio Teresa, Zambruno Giovanna, Nagy Janice A, Dvorak Harold F, Ylä-Herttuala Seppo, Shibuya Masabumi, Alitalo Kari, ;2007;The Journal of experimental medicine;204;1431-40; 17535974
- Increased melanoma growth and metastasis spreading in mice overexpressing placenta growth factor.;Marcellini Marcella, De Luca Naomi, Riccioni Teresa, Ciucci Alessandro, Orecchia Angela, Lacal Pedro Miguel, Ruffini Federica, Pesce Maurizio, Cianfarani Francesca, Zambruno Giovanna, Orlandi Augusto, Failla Cristina Maria, ;2006;The American journal of pathology;169;643-54; 16877362