C57BL/6N-Alpk3tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:09571
International strain nameC57BL/6N-Alpk3tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0752_2_F08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAlpk3tm1a(EUCOMM)Hmgu
Gene/Transgene symbolAlpk3
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0752_2_F08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • dilated heart left ventricle / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • decreased cardiac muscle contractility / IMPC
  • enlarged heart / IMPC
  • increased heart weight / IMPC
  • increased heart left ventricle size / IMPC
  • thick ventricular wall / IMPC
MGI phenotypes (gene matching)
  • enlarged heart / MGI
  • abnormal myocardial fiber morphology / MGI
  • cardiac hypertrophy / MGI
  • dilated heart left ventricle / MGI
  • increased heart weight / MGI
  • thick ventricular wall / MGI
  • decreased cardiac output / MGI
  • decreased cardiac muscle contractility / MGI
  • abnormal myocardium layer morphology / MGI
  • cardiomyopathy / MGI
  • decreased ventricle muscle contractility / MGI
  • decreased systemic arterial systolic blood pressure / MGI
  • abnormal intercalated disk morphology / MGI
  • abnormal heart layer morphology / MGI
  • myocardial hypertrophy / MGI
  • thick interventricular septum / MGI
  • abnormal heart left ventricle pressure / MGI
  • decreased cardiac stroke volume / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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