- preweaning lethality, complete penetrance / IMPC
- abnormal embryo size / IMPC
- decreased total retina thickness / IMPC
- abnormal retina inner nuclear layer morphology / IMPC
- abnormal embryo development / IMPC
- abnormal embryo turning / IMPC
- embryonic growth retardation / IMPC
- abnormal retina vasculature morphology / IMPC
- abnormal neural tube closure / IMPC
- embryonic lethality prior to tooth bud stage / IMPC
C57BL/6NTac-Csktm1(EGFP/cre/ERT2)Wtsi/WtsiIeg
Status | Available to order |
EMMA ID | EM:09554 |
International strain name | C57BL/6NTac-Csktm1(EGFP/cre/ERT2)Wtsi/WtsiIeg |
Alternative name | CEPD0036_2_E05 |
Strain type | |
Allele/Transgene symbol | Csktm1(EGFP/cre/ERT2)Wtsi |
Gene/Transgene symbol | Csk |
Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from EUCOMM ES clone CEPD0036_2_E05. For further details on the construction of this clone see the page at the IMPC portal. Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal heart development / MGI
- cellular necrosis / MGI
- megacephaly / MGI
- incomplete rostral neuropore closure / MGI
- open neural tube / MGI
- wavy neural tube / MGI
- absent notochord / MGI
- abnormal cranial ganglia morphology / MGI
- abnormal lens induction / MGI
- abnormal social investigation / MGI
- decreased anxiety-related response / MGI
- abnormal food preference / MGI
- abnormal object recognition memory / MGI
- poor circulation / MGI
- decreased embryo size / MGI
- incomplete embryo turning / MGI
- absent vitelline blood vessels / MGI
- absent visceral yolk sac blood islands / MGI
- abnormal allantois morphology / MGI
- embryonic growth arrest / MGI
- abnormal neural tube morphology / MGI
- no abnormal phenotype detected / MGI
- delayed neural tube closure / MGI
- absent olfactory bulb / MGI
- embryonic growth retardation / MGI
- caudal body truncation / MGI
- abnormal embryonic neuroepithelium morphology / MGI
- enlarged allantois / MGI
- cellular phenotype / MGI
- abnormal otic vesicle development / MGI
- absent nasal placodes / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- abnormal cephalic neural fold morphology / MGI
- absent optic placodes / MGI
- decreased embryonic neuroepithelium thickness / MGI
- incomplete caudal neuropore closure / MGI
- embryo tissue necrosis / MGI
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