C57BL/6NTac-Hnf4atm1(EGFP/cre/ERT2)Wtsi/WtsiIeg

Status

Available to order

EMMA IDEM:09551
International strain nameC57BL/6NTac-Hnf4atm1(EGFP/cre/ERT2)Wtsi/WtsiIeg
Alternative nameCEPD0035_3_D09
Strain type
Allele/Transgene symbolHnf4atm1(EGFP/cre/ERT2)Wtsi
Gene/Transgene symbolHnf4a

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone CEPD0035_3_D09. For further details on the construction of this clone see the page at the IMPC portal.
Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased circulating HDL cholesterol level / IMPC
  • increased total retina thickness / IMPC
  • persistence of hyaloid vascular system / IMPC
  • enlarged thyroid gland / IMPC
  • abnormal retina blood vessel morphology / IMPC
  • increased circulating bilirubin level / IMPC
  • increased circulating calcium level / IMPC
  • abnormal lens morphology / IMPC
  • abnormal retina morphology / IMPC
  • cataract / IMPC
  • improved glucose tolerance / IMPC
  • abnormal retina vasculature morphology / IMPC
  • decreased body weight / IMPC
  • increased circulating cholesterol level / IMPC
MGI phenotypes (gene matching)
  • abnormal embryo development / MGI
  • abnormal ectoderm development / MGI
  • absent mesoderm / MGI
  • abnormal gastrulation / MGI
  • decreased embryo size / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal extraembryonic tissue morphology / MGI
  • abnormal lipid homeostasis / MGI
  • no abnormal phenotype detected / MGI
  • abnormal primitive streak formation / MGI
  • increased circulating ketone body level / MGI
  • hepatic steatosis / MGI
  • decreased circulating triglyceride level / MGI
  • decreased circulating free fatty acid level / MGI
  • absent allantois / MGI
  • increased ectoderm apoptosis / MGI
  • embryonic growth retardation / MGI
  • hypokalemia / MGI
  • decreased circulating iron level / MGI
  • absent amnion / MGI
  • decreased circulating cholesterol level / MGI
  • impaired glucose tolerance / MGI
  • increased circulating bilirubin level / MGI
  • absent chorion / MGI
  • embryonic lethality, complete penetrance / MGI
  • preweaning lethality, complete penetrance / MGI
  • delayed gastrulation / MGI
  • small visceral yolk sac / MGI
  • increased embryonic tissue cell apoptosis / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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