C57BL/6N-Sun1tm1a(EUCOMM)Wtsi/CipheOrl

Status

Available to order

EMMA IDEM:09532
Citation informationRRID:IMSR_EM:09532 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Sun1tm1a(EUCOMM)Wtsi/CipheOrl
Alternative nameEPD0325_5_F03
Strain typeTargeted Mutant Strains
Allele/Transgene symbolSun1tm1a(EUCOMM)Wtsi
Gene/Transgene symbolSun1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Centre d'ImmunoPhenomique - Ciphe
Provider affiliationCentre d
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0325_5_F03. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6N males

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased monocyte cell number / IMPC
  • abnormal auditory brainstem response / IMPC
  • small superior vagus ganglion / IMPC
  • small testis / IMPC
  • decreased lean body mass / IMPC
  • decreased total retina thickness / IMPC
  • increased circulating phosphate level / IMPC
  • decreased circulating serum albumin level / IMPC
  • decreased prepulse inhibition / IMPC
  • abnormal retina outer nuclear layer morphology / IMPC
  • increased total body fat amount / IMPC
  • abnormal startle reflex / IMPC
  • male infertility / IMPC
  • decreased startle reflex / IMPC
  • increased neutrophil cell number / IMPC
  • abnormal retina morphology / IMPC
  • increased leukocyte cell number / IMPC
  • increased lymphocyte cell number / IMPC
  • decreased circulating total protein level / IMPC
  • increased heart rate / IMPC
  • female infertility / IMPC
  • decreased locomotor activity / IMPC
  • decreased lymphocyte cell number / IMPC
MGI phenotypes (gene matching)
  • small cerebellum / MGI
  • abnormal cerebellum development / MGI
  • abnormal cerebellar foliation / MGI
  • abnormal cerebellum external granule cell layer morphology / MGI
  • abnormal Purkinje cell morphology / MGI
  • ectopic Purkinje cell / MGI
  • small ovary / MGI
  • small testis / MGI
  • ataxia / MGI
  • impaired coordination / MGI
  • male infertility / MGI
  • female infertility / MGI
  • abnormal muscle morphology / MGI
  • decreased brain weight / MGI
  • absent ovarian follicles / MGI
  • no phenotypic analysis / MGI
  • abnormal cochlear outer hair cell morphology / MGI
  • cochlear outer hair cell degeneration / MGI
  • absent oocytes / MGI
  • decreased testis weight / MGI
  • decreased male germ cell number / MGI
  • azoospermia / MGI
  • abnormal female meiosis / MGI
  • abnormal male meiosis / MGI
  • absent pinna reflex / MGI
  • abnormal spermatocyte morphology / MGI
  • arrest of male meiosis / MGI
  • absent cerebellum fissure / MGI
  • abnormal chromosomal synapsis / MGI
  • abnormal Purkinje cell migration / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • increased ovary apoptosis / MGI
  • increased testis apoptosis / MGI
  • abnormal meiotic attachment of telomere to nuclear envelope / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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