STOCK Tg(CYP19A1-icre)3Fcrt/Biat
| Status | Available to order |
| EMMA ID | EM:09527 |
| Citation information | RRID:IMSR_EM:09527 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Tg(CYP19A1-icre)3Fcrt/Biat |
| Alternative name | Aromatase-iCre |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CYP19A1-icre)3Fcrt |
| Gene/Transgene symbol | Tg(CYP19A1-icre)3Fcrt |
Information from provider
| Provider | Philippe Monget |
| Provider affiliation | INRA |
| Genetic information | The aromatase-iCre transgene was generated by placing the cDNA encoding a mammalian codon-improved Cre recombinase (iCre) followed by an SV40 poly(A) signal under control of the human Cyp19/aromatase(IIa)-278 promoter |
| Phenotypic information | Homozygous:Expression of iCre in Leydig and Sertoli cells.Heterozygous:Expression of iCre in Leydig and Sertoli cells. |
| Breeding history | F1 animals were backcrossed 3 times to obtain individuals that were intercrossed for at least 30 generations |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | homozygous C57BL/6J males, wild-type C57BL/6J females |
| Stage of embryos | 2-cell |
Literature references
- Expression of dominant-negative thyroid hormone receptor alpha1 in Leydig and Sertoli cells demonstrates no additional defect compared with expression in Sertoli cells only.;Fumel Betty, Froment Pascal, Holzenberger Martin, Livera Gabriel, Monget Philippe, Fouchécourt Sophie, ;2015;PloS one;10;e0119392; 25793522