- increased total body fat amount / IMPC
- increased circulating alanine transaminase level / IMPC
- decreased hemoglobin content / IMPC
- decreased lean body mass / IMPC
- increased circulating glucose level / IMPC
- decreased lymphocyte cell number / IMPC
- decreased locomotor activity / IMPC
- increased circulating aspartate transaminase level / IMPC
- increased neutrophil cell number / IMPC
- increased freezing behavior / IMPC
C57BL/6NTac-Adora2atm1(EGFP/cre/ERT2)Wtsi/Cnrm
Status | Available to order |
EMMA ID | EM:09507 |
International strain name | C57BL/6NTac-Adora2atm1(EGFP/cre/ERT2)Wtsi/Cnrm |
Alternative name | CEPD0046_1_A02 |
Strain type | |
Allele/Transgene symbol | Adora2atm1(EGFP/cre/ERT2)Wtsi |
Gene/Transgene symbol | Adora2a |
Information from provider
Provider | CNR, Consiglio Nazionale delle Ricerche |
Provider affiliation | EMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche |
Genetic information | This mouse line originates from EUCOMM ES clone CEPD0046_1_A02. For further details on the construction of this clone see the page at the IMPC portal. Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- heart right ventricle hypertrophy / MGI
- abnormal pulmonary artery morphology / MGI
- increased aggression towards males / MGI
- increased anxiety-related response / MGI
- hypoactivity / MGI
- decreased exploration in new environment / MGI
- abnormal liquid preference / MGI
- abnormal cardiovascular system physiology / MGI
- increased thermal nociceptive threshold / MGI
- increased heart rate / MGI
- abnormal sclera morphology / MGI
- increased systemic arterial blood pressure / MGI
- vascular smooth muscle hypertrophy / MGI
- hypoalgesia / MGI
- myopia / MGI
- abnormal locomotor activation / MGI
- pulmonary hypertension / MGI
- nervous system phenotype / MGI
- abnormal lung vasculature morphology / MGI
- cardiovascular system phenotype / MGI
- vision/eye phenotype / MGI
- decreased cerebral infarction size / MGI
- decreased susceptibility to ischemic brain injury / MGI
- increased body mass index / MGI
- decreased interleukin-10 secretion / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased platelet aggregation / MGI
- impaired behavioral response to addictive substance / MGI
- impaired behavioral response to alcohol / MGI
- increased right ventricle systolic pressure / MGI
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