IMPC phenotypes (gene matching)
B6;129P2-Tm7sf2tm1Riro/Cnrm
| Status | Available to order |
| EMMA ID | EM:09504 |
| Citation information | RRID:IMSR_EM:09504 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Tm7sf2tm1Riro/Cnrm |
| Alternative name | Tm7sf2 KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tm7sf2tm1Riro |
| Gene/Transgene symbol | Tm7sf2 |
Information from provider
| Provider | Rita Roberti |
| Provider affiliation | Experimental medicine, University of Perugia |
| Genetic information | Null mutation of Tm7sf2 gene. |
| Phenotypic information | Homozygous:No apparent phenotype. Reduced cholesterol synthesis in stress conditions.Heterozygous:No phenotype. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | not known |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis.;Bennati Anna M, Schiavoni Gianluca, Franken Sebastian, Piobbico Danilo, Della Fazia Maria A, Caruso Donatella, De Fabiani Emma, Benedetti Laura, Cusella De Angelis Maria G, Gieselmann Volkmar, Servillo Giuseppe, Beccari Tommaso, Roberti Rita, ;2008;The FEBS journal;275;5034-47; 18785926
- A novel role for Tm7sf2 gene in regulating TNFα expression.;Bellezza Ilaria, Roberti Rita, Gatticchi Leonardo, Del Sordo Rachele, Rambotti Maria Grazia, Marchetti Maria Cristina, Sidoni Angelo, Minelli Alba, ;2013;PloS one;8;e68017; 23935851
- The loss of Tm7sf gene accelerates skin papilloma formation in mice.;Bellezza I, Gatticchi L, del Sordo R, Peirce M J, Sidoni A, Roberti R, Minelli A, ;2015;Scientific reports;5;9471; 25804527