C57BL/6N-Atm1Brd Sgms1tm1a(EUCOMM)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:09471
International strain nameC57BL/6N-Atm1Brd Sgms1tm1a(EUCOMM)Wtsi/WtsiH
Alternative nameEPD0725_2_G05
Strain typeTargeted Mutant Strains
Allele/Transgene symbolSgms1tm1a(EUCOMM)Wtsi
Gene/Transgene symbolSgms1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0725_2_G05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • A new mutation of Sgms1 causes gradual hearing loss associated with a reduced endocochlear potential.;Chen Jing, Lewis Morag A, Wai Alisa, Yin Lucia, Dawson Sally J, Ingham Neil J, Steel Karen P, ;2024;Hearing research;451;109091; 39067415

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)
  • tremors / IMPC
  • male infertility / IMPC
  • increased mean platelet volume / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • thrombocytopenia / IMPC
  • increased lean body mass / IMPC
  • increased circulating creatinine level / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • decreased total body fat amount / IMPC
  • increased grip strength / IMPC
  • increased circulating magnesium level / IMPC
IMPC phenotypes (gene matching)
  • decreased mean corpuscular hemoglobin / IMPC
  • increased grip strength / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased mean platelet volume / IMPC
  • male infertility / IMPC
  • increased lean body mass / IMPC
  • decreased total body fat amount / IMPC
  • thrombocytopenia / IMPC
  • tremors / IMPC
  • increased circulating creatinine level / IMPC
  • increased circulating magnesium level / IMPC
MGI phenotypes (gene matching)
  • decreased body weight / MGI
  • hyperglycemia / MGI
  • decreased white adipose tissue amount / MGI
  • premature death / MGI
  • decreased circulating insulin level / MGI
  • increased insulin sensitivity / MGI
  • abnormal cytokine secretion / MGI
  • decreased insulin secretion / MGI
  • oxidative stress / MGI
  • abnormal pancreatic islet morphology / MGI
  • impaired glucose tolerance / MGI
  • homeostasis/metabolism phenotype / MGI
  • decreased circulating tumor necrosis factor level / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased circulating interleukin-6 level / MGI
  • decreased interleukin-6 secretion / MGI
  • abnormal cytokine level / MGI
  • abnormal sphingomyelin level / MGI
  • abnormal ceramide level / MGI

Literature references

  • A new mutation of Sgms1 causes gradual hearing loss associated with a reduced endocochlear potential.;Chen Jing, Lewis Morag A, Wai Alisa, Yin Lucia, Dawson Sally J, Ingham Neil J, Steel Karen P, ;2024;Hearing research;451;109091; 39067415

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).