C57BL/6-Tg(Myh6-Akt1*)6445Gcon/Cnrm
| Status | Available to order |
| EMMA ID | EM:09465 |
| Citation information | RRID:IMSR_EM:09465 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Tg(Myh6-Akt1*)6445Gcon/Cnrm |
| Alternative name | Akt-E40K |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Myh6-Akt1*)6445Gcon |
| Gene/Transgene symbol | Tg(Myh6-Akt1*)6445Gcon |
Information from provider
| Provider | Gianluigi Condorelli |
| Provider affiliation | Humanitas |
| Genetic information | Cardiac-specific (alpha-myosin heavy chain promoter) expression of the dominant active protein kinase Akt (PKB), Akt-E40K. |
| Phenotypic information | Homozygous:Not performed.Heterozygous:Akt overexpression produced cardiac hypertrophy at the molecular and histological levels, with a significant increase in cardiomyocyte cell size and concentric left ventricular hypertrophy. Akt-transgenic mice also showed a remarkable increase in cardiac contractility compared with wild-type controls as demonstrated by the analysis of left ventricular (dP/dtmax) in an invasive hemodynamic study, although with graded dobutamine infusion, the maximum response was not different from that in controls. Diastolic function, evaluated by left ventricular dP/dtmin, was not affected at rest but was impaired during graded dobutamine infusion. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice.;Condorelli Gianluigi, Drusco Alessandra, Stassi Giorgio, Bellacosa Alfonso, Roncarati Roberta, Iaccarino Guido, Russo Matteo A, Gu Yusu, Dalton Nancy, Chung Clarence, Latronico Michael V G, Napoli Claudio, Sadoshima Junichi, Croce Carlo M, Ross John, ;2002;Proceedings of the National Academy of Sciences of the United States of America;99;12333-8; 12237475