C57BL/6NTac-Hoxa3tm1(EGFP/cre/ERT2)Wtsi/Cnrm

Status

Available to order

EMMA IDEM:09448
International strain nameC57BL/6NTac-Hoxa3tm1(EGFP/cre/ERT2)Wtsi/Cnrm
Alternative nameCEPD0036_1_D06
Strain type
Allele/Transgene symbolHoxa3tm1(EGFP/cre/ERT2)Wtsi
Gene/Transgene symbolHoxa3

Information from provider

Provider CNR, Consiglio Nazionale delle Ricerche
Provider affiliationEMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche
Genetic informationThis mouse line originates from EUCOMM ES clone CEPD0036_1_D06. For further details on the construction of this clone see the page at the IMPC portal.
Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm1(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • short mandible / MGI
  • short maxilla / MGI
  • absent parathyroid glands / MGI
  • abnormal thyroid gland morphology / MGI
  • athymia / MGI
  • abnormal somatic motor system morphology / MGI
  • abnormal glossopharyngeal nerve morphology / MGI
  • distended abdomen / MGI
  • neonatal lethality / MGI
  • perinatal lethality / MGI
  • abnormal muscle morphology / MGI
  • abnormal cardiovascular system morphology / MGI
  • abnormal respiratory system morphology / MGI
  • abnormal larynx morphology / MGI
  • abnormal cricoid cartilage morphology / MGI
  • abnormal thyroid cartilage morphology / MGI
  • abnormal trachea morphology / MGI
  • persistent truncus arteriosis / MGI
  • abnormal vein morphology / MGI
  • dilated heart left ventricle / MGI
  • abnormal pharyngeal arch morphology / MGI
  • small thyroid gland / MGI
  • abnormal cervical vertebrae morphology / MGI
  • abnormal hyoid bone morphology / MGI
  • abnormal soft palate morphology / MGI
  • abnormal facial morphology / MGI
  • abnormal ultimobranchial body morphology / MGI
  • abnormal tongue muscle morphology / MGI
  • small trachea / MGI
  • fusion of glossopharyngeal and vagus nerve / MGI
  • abnormal clavicle morphology / MGI
  • growth/size/body region phenotype / MGI
  • endocrine/exocrine gland phenotype / MGI
  • digestive/alimentary phenotype / MGI
  • craniofacial phenotype / MGI
  • immune system phenotype / MGI
  • respiratory system phenotype / MGI
  • abnormal heart size / MGI
  • abnormal skeleton morphology / MGI
  • aortic valve stenosis / MGI
  • abnormal fourth pharyngeal arch morphology / MGI
  • abnormal hyoid bone greater horn morphology / MGI
  • abnormal hyoid bone lesser horn morphology / MGI
  • absent hyoid bone lesser horns / MGI
  • abnormal epiglottis morphology / MGI
  • bicuspid pulmonary valve / MGI
  • aorta hypoplasia / MGI
  • mortality/aging / MGI
  • perinatal lethality, complete penetrance / MGI
  • larynx stenosis / MGI
  • abnormal thyroid gland isthmus morphology / MGI
  • absent thyroid gland isthmus / MGI
  • short soft palate / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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