IMPC phenotypes (gene matching)
STOCK Pax7tm1(cre)Mrc Mapk14tm2Nbr/JpellH
| Status | Available to order |
| EMMA ID | EM:09446 |
| Citation information | RRID:IMSR_EM:09446 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Pax7tm1(cre)Mrc Mapk14tm2Nbr/JpellH |
| Alternative name | C57BL/6J- Mapk14tm2Nbr Pax7tm1(cre)Mrc |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Mapk14tm2Nbr, Pax7tm1(cre)Mrc |
| Gene/Transgene symbol | Mapk14, Pax7 |
Information from provider
| Provider | Sarah Shorne |
| Provider affiliation | Pharmacology, University of Cambridge |
| Genetic information | Knock-out of Mapk14/p38alpha only in the presence of cre recombinase. |
| Phenotypic information | Homozygous:Very mild growth retardation.Heterozygous:Unsure if exhibited in heterozygote. |
| Breeding history | p38flox mice, expressing loxP-flanked Mapk14/p38alpha, crossed with Pax7-cre mice. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | not known |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal erythropoiesis / MGI
- abnormal angiogenesis / MGI
- absent myocardial trabeculae / MGI
- altered response to myocardial infarction / MGI
- small liver / MGI
- pale liver / MGI
- anemia / MGI
- abnormal blood vessel morphology / MGI
- poor circulation / MGI
- abnormal placenta morphology / MGI
- abnormal placenta development / MGI
- decreased trophoblast giant cell number / MGI
- abnormal placenta labyrinth morphology / MGI
- pale yolk sac / MGI
- no abnormal phenotype detected / MGI
- thin myocardium / MGI
- decreased myocardial infarction size / MGI
- abnormal placenta vasculature / MGI
- absent placental labyrinth / MGI
- pallor / MGI
- embryonic growth retardation / MGI
- abnormal vitelline vascular remodeling / MGI
- abnormal muscle fiber morphology / MGI
- abnormal trophoblast layer morphology / MGI
- increased double-negative T cell number / MGI
- decreased T cell proliferation / MGI
- decreased cardiac muscle contractility / MGI
- hematopoietic system phenotype / MGI
- abnormal T-helper 1 physiology / MGI
- decreased circulating glucose level / MGI
- abnormal cell physiology / MGI
- embryonic lethality during organogenesis / MGI
- impaired placental function / MGI
- decreased interferon-alpha secretion / MGI
- decreased interferon-gamma secretion / MGI
- abnormal fetal cardiomyocyte morphology / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- decreased placental labyrinth size / MGI
- abnormal myoblast differentiation / MGI
- increased pancreatic beta cell proliferation / MGI
- decreased pancreatic beta cell proliferation / MGI
- decreased spongiotrophoblast size / MGI
- increased embryonic tissue cell apoptosis / MGI
- short maxilla / MGI
- pointed snout / MGI
- abnormal small intestine morphology / MGI
- muscle weakness / MGI
- abnormal muscle regeneration / MGI
- thin diaphragm muscle / MGI
- decreased body size / MGI
- postnatal growth retardation / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- no phenotypic analysis / MGI
- nervous system phenotype / MGI
- decreased satellite cell number / MGI
- myositis / MGI
- abnormal nasal capsule morphology / MGI
- decreased skeletal muscle mass / MGI
- cachexia / MGI
- muscle phenotype / MGI
- embryo phenotype / MGI
- digestive/alimentary phenotype / MGI
- cellular phenotype / MGI
- abnormal serous gland morphology / MGI
- decreased skeletal muscle fiber diameter / MGI
- skeletal muscle fibrosis / MGI
- decreased birth body size / MGI
- decreased skeletal muscle weight / MGI
- postnatal lethality, incomplete penetrance / MGI
Literature references
- Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development.;Adams R H, Porras A, Alonso G, Jones M, Vintersten K, Panelli S, Valladares A, Perez L, Klein R, Nebreda A R, ;2000;Molecular cell;6;109-16; 10949032
- Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.;Keller Charles, Hansen Mark S, Coffin Cheryl M, Capecchi Mario R, ;2004;Genes & development;18;2608-13; 15520281