C57BL/6N-Notch1tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:09421
International strain nameC57BL/6N-Notch1tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0627_7_B12
Strain typeTargeted Mutant Strains
Allele/Transgene symbolNotch1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolNotch1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0627_7_B12. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased grip strength / IMPC
  • increased startle reflex / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • abnormal vertebrae morphology / IMPC
MGI phenotypes (gene matching)
  • abnormal vertebrae morphology / MGI
  • abnormal vascular development / MGI
  • abnormal heart development / MGI
  • distended pericardium / MGI
  • trabecula carnea hypoplasia / MGI
  • abnormal cell death / MGI
  • decreased thymocyte number / MGI
  • abnormal trigeminal ganglion morphology / MGI
  • anemia / MGI
  • abnormal vasculogenesis / MGI
  • abnormal somite development / MGI
  • decreased embryo size / MGI
  • absent vitelline blood vessels / MGI
  • pale yolk sac / MGI
  • embryonic growth arrest / MGI
  • postnatal growth retardation / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal T cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • disorganized myocardium / MGI
  • abnormal artery morphology / MGI
  • abnormal placenta vasculature / MGI
  • kinked neural tube / MGI
  • delayed somite formation / MGI
  • abnormal nervous system development / MGI
  • embryonic growth retardation / MGI
  • abnormal embryonic neuroepithelium morphology / MGI
  • increased cochlear outer hair cell number / MGI
  • notochord degeneration / MGI
  • abnormal dorsal aorta morphology / MGI
  • decreased T cell number / MGI
  • decreased double-negative T cell number / MGI
  • abnormal rostral-caudal axis patterning / MGI
  • abnormal somite size / MGI
  • abnormal left-right axis symmetry of the somites / MGI
  • abnormal myocardium layer morphology / MGI
  • decreased angiogenesis / MGI
  • embryonic lethality during organogenesis / MGI
  • small pharyngeal arch / MGI
  • increased T cell apoptosis / MGI
  • embryonic lethality / MGI
  • abnormal cardiac epithelial to mesenchymal transition / MGI
  • abnormal retinal blood vessel morphology / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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Legally binding conditions for the transfer

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