C.Cg-Tg(Tcra,Tcrb)562Biat/Biat
| Status | Available to order |
| EMMA ID | EM:09382 |
| International strain name | C.Cg-Tg(Tcra,Tcrb)562Biat/Biat |
| Alternative name | C.CB6-Tg(Tcra,Tcrb)562Biat |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Tcra,Tcrb)562Biat |
| Gene/Transgene symbol | Tg(Tcra,Tcrb)562Biat |
Information from provider
| Provider | Burkhard Ludewig |
| Provider affiliation | Institut für Immunbiologie, Kantonsspital St. Gallen |
| Additional owner | Prof. Thomas Rülicke, University of Veterinary Medicine, Vienna, Austria |
| Genetic information | Transgenic line produced by pronuclear injection of a transgene; random integration with unknown integration site; defined background. |
| Phenotypic information | Homozygous:Unknown.Heterozygous:Spontaneously developing autoimmune myocarditis that progresses to lethal DCM. Cardiac magnetic resonance imaging revealed early inflammation-associated changes in the ventricle wall, including transient thickening of the left ventricle wall. Furthermore, we found that IFN-gamma was a major effector cytokine driving the initial inflammatory process and that the cooperation of IFN-gamma and IL-17A was essential for the development of the progressive disease. This novel TCR transgenic mouse model permits the identification of the central pathophysiological and immunological processes involved in the transition from autoimmune myocarditis to DCM. |
| Breeding history | Mating of founder with BALB/c. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Literature references
- Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy.;Nindl Veronika, Maier Reinhard, Ratering David, De Giuli Rita, Züst Roland, Thiel Volker, Scandella Elke, Di Padova Franco, Kopf Manfred, Rudin Markus, Rülicke Thomas, Ludewig Burkhard, ;2012;European journal of immunology;42;2311-21; 22730043