C57BL/6N-Tg(Ccl19-cre)489Biat/Biat
| Status | Available to order |
| EMMA ID | EM:09381 |
| International strain name | C57BL/6N-Tg(Ccl19-cre)489Biat/Biat |
| Alternative name | C57BL/6N-Tg(Ccl19-Cre)489Biat |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Ccl19-cre)489Biat |
| Gene/Transgene symbol | Tg(Ccl19-cre)489Biat |
Information from provider
| Provider | Burkhard Ludewig |
| Provider affiliation | Institut für Immunbiologie, Kantonsspital St. Gallen |
| Additional owner | Prof. Thomas Rülicke, University of Veterinary Medicine, Vienna, Austria |
| Genetic information | Transgenic line produced by pronuclear injection of a BAC transgene; random integration with unknown integration site; defined background. |
| Phenotypic information | Homozygous:Tissue-specific expression of cre-recombinase; no own phenotype.Heterozygous:Tissue-specific expression of cre-recombinase; no own phenotype. |
| Breeding history | Mating of founder with C57BL/6N. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | heterozygous C57BL/6N |
Literature references
- Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity.;Chai Qian, Onder Lucas, Scandella Elke, Gil-Cruz Cristina, Perez-Shibayama Christian, Cupovic Jovana, Danuser Renzo, Sparwasser Tim, Luther Sanjiv A, Thiel Volker, Rülicke Thomas, Stein Jens V, Hehlgans Thomas, Ludewig Burkhard, ;2013;Immunity;38;1013-24; 23623380
- IL-17-dependent fibroblastic reticular cell training boosts tissue protective mucosal immunity through IL-10-producing B cells.;Wu Dongwen, Poholek Catherine H, Majumder Saikat, Liu Qixing, Revu Shankar K, Mohib Kanishka, Rothstein David M, McGeachy Mandy J, ;2021;Science immunology;6;eaao3669; 34919443
- Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25.;Kim Dongeon, Kim Mingyo, Kim Tae Woo, Choe Yong-Ho, Noh Hae Sook, Jeon Hyun Min, Kim HyunSeok, Lee Youngeun, Hur Gayeong, Lee Kyung-Mi, Shin Kihyuk, Lee Sang-Il, Lee Seung-Hyo, ;2022;The Journal of experimental medicine;219;2972-2983; 35315876
- The conduit system exports locally secreted IgM from lymph nodes.;Thierry Guilhem R, Kuka Mirela, De Giovanni Marco, Mondor Isabelle, Brouilly Nicolas, Iannacone Matteo, Bajénoff Marc, ;2018;The Journal of experimental medicine;215;3903; 30429248
- Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes.;Pezoldt Joern, Pasztoi Maria, Zou Mangge, Wiechers Carolin, Beckstette Michael, Thierry Guilhem R, Vafadarnejad Ehsan, Floess Stefan, Arampatzi Panagiota, Buettner Manuela, Schweer Janina, Fleissner Diana, Vital Marius, Pieper Dietmar H, Basic Marijana, Dersch Petra, Strowig Till, Hornef Mathias, Bleich André, Bode Ulrike, Pabst Oliver, Bajénoff Marc, Saliba Antoine-Emmanuel, Huehn Jochen, ;2018;Nature communications;9;; 30254319