IMPC phenotypes (allele matching)
C57BL/6N-Plac8tm1b(EUCOMM)Hmgu/Ieg
| Status | Available to order |
| EMMA ID | EM:09378 |
| International strain name | C57BL/6N-Plac8tm1b(EUCOMM)Hmgu/Ieg |
| Alternative name | HEPD0679_1_B07 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Plac8tm1b(EUCOMM)Hmgu |
| Gene/Transgene symbol | Plac8 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | This mouse line originates from EUCOMM ES clone HEPD0679_1_B07. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele. Click here for more information on EUCOMM final vectors. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6NTac |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- increased body weight / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal neutrophil physiology / MGI
- increased vascular permeability / MGI
- decreased body temperature / MGI
- increased brown fat cell lipid droplet size / MGI
- decreased brown fat lipid droplet number / MGI
- impaired adaptive thermogenesis / MGI
- increased body fat mass / MGI
- whitened brown adipose tissue morphology / MGI