B6.Cg-Tg(Camk2a-rtTA2*M2)4Rsp/Kctt
| Status | Available to order |
| EMMA ID | EM:09321 |
| International strain name | B6.Cg-Tg(Camk2a-rtTA2*M2)4Rsp/Kctt |
| Alternative name | TgCaMKII-rtTA2-nM2 (lab name M2n#4) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Camk2a-rtTA2*M2)4Rsp |
| Gene/Transgene symbol | Tg(Camk2a-rtTA2*M2)4Rsp |
Information from provider
| Provider | Rolf Sprengel |
| Provider affiliation | Molecular Neurobiology, Max Planck Institute for Medical Research |
| Genetic information | The transgene TgCaMKII-rtTA2-nM2 drives the expression of the Doxycycline inducible and optimised transcription factor rtTA2-nM2 specifically in neurons of the forebrain under the control of the promoter fragment for the alpha subunit of CaMKII. The transcription factor rtTA2-nM2 contains a nuclear localization signal. |
| Phenotypic information | Homozygous:not knownHeterozygous:No obvious phenotype |
| Breeding history | Transgenic founders were backcrossed to C57BL/6 mice for several generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous C57BL/6 |
Literature references
- Silencing and un-silencing of tetracycline-controlled genes in neurons.;Zhu Peixin, Aller M Isabel, Baron Udo, Cambridge Sidney, Bausen Melanie, Herb Jan, Sawinski Jürgen, Cetin Ali, Osten Pavel, Nelson Mark L, Kügler Sebastian, Seeburg Peter H, Sprengel Rolf, Hasan Mazahir T, ;2007;PloS one;2;e533; 17579707