B6.Cg-Tg(Camk2a-rtTA2*M2)4Rsp/Kctt

Status

Available to order

EMMA IDEM:09321
International strain nameB6.Cg-Tg(Camk2a-rtTA2*M2)4Rsp/Kctt
Alternative nameTgCaMKII-rtTA2-nM2 (lab name M2n#4)
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Camk2a-rtTA2*M2)4Rsp
Gene/Transgene symbolTg(Camk2a-rtTA2*M2)4Rsp

Information from provider

ProviderRolf Sprengel
Provider affiliationMolecular Neurobiology, Max Planck Institute for Medical Research
Genetic informationThe transgene TgCaMKII-rtTA2-nM2 drives the expression of the Doxycycline inducible and optimised transcription factor rtTA2-nM2 specifically in neurons of the forebrain under the control of the promoter fragment for the alpha subunit of CaMKII. The transcription factor rtTA2-nM2 contains a nuclear localization signal.
Phenotypic informationHomozygous:
not known

Heterozygous:
No obvious phenotype
Breeding historyTransgenic founders were backcrossed to C57BL/6 mice for several generations.
References
  • Silencing and un-silencing of tetracycline-controlled genes in neurons.;Zhu Peixin, Aller M Isabel, Baron Udo, Cambridge Sidney, Bausen Melanie, Herb Jan, Sawinski Jürgen, Cetin Ali, Osten Pavel, Nelson Mark L, Kügler Sebastian, Seeburg Peter H, Sprengel Rolf, Hasan Mazahir T, ;2007;PloS one;2;e533; 17579707
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedyes

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden
Animals used for archivingheterozygous C57BL/6

Literature references

  • Silencing and un-silencing of tetracycline-controlled genes in neurons.;Zhu Peixin, Aller M Isabel, Baron Udo, Cambridge Sidney, Bausen Melanie, Herb Jan, Sawinski Jürgen, Cetin Ali, Osten Pavel, Nelson Mark L, Kügler Sebastian, Seeburg Peter H, Sprengel Rolf, Hasan Mazahir T, ;2007;PloS one;2;e533; 17579707

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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