B6.Cg-Tg(Camk2a-rtTA2*M2)2Rsp/Kctt
| Status | Available to order |
| EMMA ID | EM:09320 |
| Citation information | RRID:IMSR_EM:09320 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(Camk2a-rtTA2*M2)2Rsp/Kctt |
| Alternative name | TgCaMKII-rtTA2-M2 (lab name M2#2) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Camk2a-rtTA2*M2)2Rsp |
| Gene/Transgene symbol | Tg(Camk2a-rtTA2*M2)2Rsp |
Information from provider
| Provider | Rolf Sprengel |
| Provider affiliation | Molecular Neurobiology, Max Planck Institute for Medical Research |
| Genetic information | The transgene "CaMKII-rtTA2-M2" drives the expression of the Doxycycline inducible and optimised transcription factor rtTA2-M2 specifically in neurons of the forebrain under the control of the promoter fragment for the alpha subunit of CaMKII. |
| Phenotypic information | Homozygous:not knownHeterozygous:No obvious phenotype |
| Breeding history | Transgenic founders were backcrossed to C57BL/6 mice for several generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous C57BL/6 males |
Literature references
- Silencing and un-silencing of tetracycline-controlled genes in neurons.;Zhu Peixin, Aller M Isabel, Baron Udo, Cambridge Sidney, Bausen Melanie, Herb Jan, Sawinski Jürgen, Cetin Ali, Osten Pavel, Nelson Mark L, Kügler Sebastian, Seeburg Peter H, Sprengel Rolf, Hasan Mazahir T, ;2007;PloS one;2;e533; 17579707