IMPC phenotypes (allele matching)
C57BL/6N-Syktm1b(EUCOMM)Hmgu/Ieg
| Status | Available to order |
| EMMA ID | EM:09307 |
| International strain name | C57BL/6N-Syktm1b(EUCOMM)Hmgu/Ieg |
| Alternative name | HEPD0722_4_A07 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Syktm1b(EUCOMM)Hmgu |
| Gene/Transgene symbol | Syk |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | This mouse line originates from EUCOMM ES clone HEPD0722_4_A07. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (Gt(ROSA)26Sortm1(ACTB-cre,-EGFP)Ics (MGI:5285392)). Click here for more information on EUCOMM final vectors. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6NTac |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased neutrophil cell number / MGI
- absent pre-B cells / MGI
- decreased bone marrow cell number / MGI
- abnormal foot pad morphology / MGI
- abnormal lung morphology / MGI
- abnormal blood vessel morphology / MGI
- arrested B cell differentiation / MGI
- decreased inflammatory response / MGI
- abnormal lymphatic vessel morphology / MGI
- hemorrhage / MGI
- intracranial hemorrhage / MGI
- intracerebral hemorrhage / MGI
- abnormal B cell differentiation / MGI
- hydrops fetalis / MGI
- abnormal dendritic cell antigen presentation / MGI
- abnormal B cell physiology / MGI
- abnormal neutrophil physiology / MGI
- impaired neutrophil phagocytosis / MGI
- increased IgM level / MGI
- glomerulonephritis / MGI
- abnormal renal glomerular capsule morphology / MGI
- increased anti-insulin autoantibody level / MGI
- increased urine protein level / MGI
- no phenotypic analysis / MGI
- lymphatic vessel hyperplasia / MGI
- dilated vasculature / MGI
- abnormal brain vasculature morphology / MGI
- decreased bone resorption / MGI
- decreased B cell number / MGI
- abnormal late pro-B cell / MGI
- impaired granulocyte bactericidal activity / MGI
- increased B cell proliferation / MGI
- immune system phenotype / MGI
- decreased circulating creatinine level / MGI
- increased circulating glucose level / MGI
- decreased blood urea nitrogen level / MGI
- spinal hemorrhage / MGI
- abnormal T cell number / MGI
- abnormal NK cell differentiation / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- decreased marginal zone B cell number / MGI
- decreased transitional stage B cell number / MGI
- decreased mature B cell number / MGI
- abnormal osteoclast differentiation / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased IgG2b level / MGI
- increased tumor necrosis factor secretion / MGI
- decreased tumor necrosis factor secretion / MGI
- abnormal lymphangiogenesis / MGI
- increased B cell apoptosis / MGI
- decreased transitional stage T1 B cell number / MGI
- decreased transitional stage T2 B cell number / MGI
- decreased DN1 thymic pro-T cell number / MGI
- increased DN3 thymocyte number / MGI
- abnormal lymphatic vessel endothelium morphology / MGI
- decreased lymphatic vessel endothelial cell number / MGI
- enlarged lymphatic vessel / MGI
- primary atelectasis / MGI
- increased CD4-positive, alpha-beta memory T cell number / MGI
- increased CD8-positive, alpha-beta memory T cell number / MGI
- postnatal lethality, complete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- abnormal renal glomerulus basement membrane morphology / MGI
- expanded mesangial matrix / MGI
- mesangial cell hyperplasia / MGI
- chylous ascites / MGI