B6;D-Tg(tetO-lacZ,-GFP/Gria2)1Rsp/Kctt
| Status | Available to order |
| EMMA ID | EM:09283 |
| International strain name | B6;D-Tg(tetO-lacZ,-GFP/Gria2)1Rsp/Kctt |
| Alternative name | TgTetOGFP-GluA2/1 (labname TgOCN1) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(tetO-lacZ,-GFP/Gria2)1Rsp |
| Gene/Transgene symbol | Tg(tetO-lacZ,-GFP/Gria2)1Rsp |
Information from provider
| Provider | Rolf Sprengel |
| Provider affiliation | Molecular Neurobiology, Max Planck Institute for Medical Research |
| Genetic information | A transgene for the N-terminal GFP tagged AMPA receptor subunit GluA2 (Gria2), together with a nuclear localised lacZ reporter gene, is under the control of the tTA-dependent bidirectional synthetic promoter. Mouse lines TgTetOGFP-GluA2/1 and TgTetOGFP-GluA2/6 are derived from two different founders from the same pronucleus injection. |
| Phenotypic information | Homozygous:Not knownHeterozygous:When activated by tTA the GFP-GluA2 transgene can partially rescue the GluA2 knock-out (Gria2-/-) mice. |
| Breeding history | Embryos from matings of hemizygote transgenes TgTet0GFP-GluA2 males and C57BL/6N females were harvested and 93 embryos were cryoconserved in January 2003 |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous C57BL/6N, wild-type C57BL/6N |
| Stage of embryos | 2-cell |
Literature references
- Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptors.;Shimshek Derya R, Bus Thorsten, Kim Jinhyun, Mihaljevic Andre, Mack Volker, Seeburg Peter H, Sprengel Rolf, Schaefer Andreas T, ;2005;PLoS biology;3;e354; 16216087