C57BL/6N-Kcnj10tm1a(KOMP)Wtsi/H

Status

Available to order

EMMA IDEM:09266
International strain nameC57BL/6N-Kcnj10tm1a(KOMP)Wtsi/H
Alternative nameEPD0528_2_E06
Strain typeTargeted Mutant Strains
Allele/Transgene symbolKcnj10tm1a(KOMP)Wtsi
Gene/Transgene symbolKcnj10
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from KOMP ES clone EPD0528_2_E06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased exploration in new environment / IMPC
  • tremors / IMPC
  • increased startle reflex / IMPC
  • decreased basophil cell number / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • decreased mean platelet volume / IMPC
MGI phenotypes (gene matching)
  • abnormal cochlea morphology / MGI
  • organ of Corti degeneration / MGI
  • abnormal stria vascularis morphology / MGI
  • tremors / MGI
  • weakness / MGI
  • hindlimb paralysis / MGI
  • abnormal myelination / MGI
  • abnormal oligodendrocyte morphology / MGI
  • abnormal spinal cord morphology / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • dehydration / MGI
  • abnormal posture / MGI
  • abnormal motor coordination/balance / MGI
  • impaired righting response / MGI
  • impaired balance / MGI
  • postnatal growth retardation / MGI
  • polyuria / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • abnormal nervous system electrophysiology / MGI
  • abnormal renal tubule morphology / MGI
  • cochlear ganglion degeneration / MGI
  • decreased urine calcium level / MGI
  • abnormal tectorial membrane morphology / MGI
  • abnormal scala media morphology / MGI
  • vestibular ganglion degeneration / MGI
  • vestibular hair cell degeneration / MGI
  • vestibular saccular macula degeneration / MGI
  • utricular macular degeneration / MGI
  • cochlear inner hair cell degeneration / MGI
  • cochlear outer hair cell degeneration / MGI
  • abnormal crista ampullaris neuroepithelium morphology / MGI
  • absent endocochlear potential / MGI
  • abnormal cochlear nerve morphology / MGI
  • abnormal eye physiology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • vision/eye phenotype / MGI
  • axon degeneration / MGI
  • jerky movement / MGI
  • abnormal eye electrophysiology / MGI
  • abnormal Reissner membrane morphology / MGI
  • collapsed Reissner membrane / MGI
  • distended Reissner membrane / MGI
  • increased urine sodium level / MGI
  • impaired hearing / MGI
  • absent pinna reflex / MGI
  • absent startle reflex / MGI
  • abnormal cochlear endolymph ionic homeostasis / MGI
  • abnormal spinal cord white matter morphology / MGI
  • postnatal lethality, complete penetrance / MGI
  • decreased urine creatinine level / MGI
  • increased or absent threshold for auditory brainstem response / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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Legally binding conditions for the transfer

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