B6;D2-Tg(tetO-lacZ,-GFP/Gria1)A1.1Rsp/Kctt

Status	Available to order
EMMA ID	EM:09257
Citation information	RRID:IMSR_EM:09257 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6;D2-Tg(tetO-lacZ,-GFP/Gria1)A1.1Rsp/Kctt
Alternative name	TgTet0GFP-GluA1 (lab name A1.1)
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(tetO-lacZ,-GFP/Gria1)A1.1Rsp
Gene/Transgene symbol	Tg(tetO-lacZ,-GFP/Gria1)A1.1Rsp

Information from provider

Provider	Rolf Sprengel
Provider affiliation	Molecular Neurobiology, Max Planck Institut for Medical Research
Genetic information	A transgene for the N-terminal, GFP-tagged AMPA receptor subunit GluA1 (Gria1), together with a nuclear localized lacZ reporter gene, is under the control of the tTA-dependent bidirectional synthetic promoter.
Phenotypic information	Homozygous: not known Heterozygous: The GFP-GluA1 transgene can partially rescue the GluA1 knock-out (Gria1-/-) phenotype
Breeding history	Embryos from matings of hemizygote transgenic TgTet0GFP-GluA1 males and (B6D2)F1 females were harvested and 278 embryos were cryoconserved in April 2006
References	Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice.;Mack V, Burnashev N, Kaiser K M, Rozov A, Jensen V, Hvalby O, Seeburg P H, Sakmann B, Sprengel R, ;2001;Science (New York, N.Y.);292;2501-4; 11431570 Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice.;Schmitt W B, Sprengel R, Mack V, Draft R W, Seeburg P H, Deacon R M J, Rawlins J N P, Bannerman D M, ;2005;Nature neuroscience;8;270-2; 15723058
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Karolinska Institutet, Stockholm, Sweden
Animals used for archiving	heterozygous C57BL/6 males

Literature references

Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice.;Mack V, Burnashev N, Kaiser K M, Rozov A, Jensen V, Hvalby O, Seeburg P H, Sakmann B, Sprengel R, ;2001;Science (New York, N.Y.);292;2501-4; 11431570
Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice.;Schmitt W B, Sprengel R, Mack V, Draft R W, Seeburg P H, Deacon R M J, Rawlins J N P, Bannerman D M, ;2005;Nature neuroscience;8;270-2; 15723058

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
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Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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