STOCK Tg(Camk2a-Grin2c/itTA)10Rsp/Kctt
| Status | Available to order |
| EMMA ID | EM:09255 |
| International strain name | STOCK Tg(Camk2a-Grin2c/itTA)10Rsp/Kctt |
| Alternative name | TgCN10 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Camk2a-Grin2c/itTA)10Rsp |
| Gene/Transgene symbol | Tg(Camk2a-Grin2c/itTA)10Rsp |
Information from provider
| Provider | Rolf Sprengel |
| Provider affiliation | Molecular Neurobiology, Max Planck Institute for Medical Research |
| Genetic information | The expression of the humanized version of the "improved" tetracycline transactivator (itTA) protein is controlled by the CamkII promoter and the neuron specific silencer of the Grin2c (glutamate receptor, ionotropic, epsilon 3) gene. The expression is restricted to granular cells of the hippocampus. |
| Phenotypic information | Homozygous:not knownHeterozygous:Very bad breeders when backcrossed to C57BL/6. |
| Breeding history | 60 het embryos (2-cells stage) generated on Oct 23, 2013 |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous NMRI |
Literature references
- Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus.;Niewoehner B, Single F N, Hvalby Ø, Jensen V, Meyer zum Alten Borgloh S, Seeburg P H, Rawlins J N P, Sprengel R, Bannerman D M, ;2007;The European journal of neuroscience;25;837-46; 17313573
- Age-Dependent Degeneration of Mature Dentate Gyrus Granule Cells Following NMDA Receptor Ablation.;Watanabe Yasuhito, Müller Michaela K, von Engelhardt Jakob, Sprengel Rolf, Seeburg Peter H, Monyer Hannah, ;2015;Frontiers in molecular neuroscience;8;87; 26793056