IMPC phenotypes (gene matching)
- increased spleen weight / IMPC
C57BL/6NTac-Selltm2(EGFP/cre/ERT2)Wtsi/Cnrm
| Status | Available to order |
| EMMA ID | EM:09222 |
| International strain name | C57BL/6NTac-Selltm2(EGFP/cre/ERT2)Wtsi/Cnrm |
| Alternative name | CEPD0087_2_C10 |
| Strain type | |
| Allele/Transgene symbol | Selltm2(EGFP/cre/ERT2)Wtsi |
| Gene/Transgene symbol | Sell |
Information from provider
| Provider | CNR, Consiglio Nazionale delle Ricerche |
| Provider affiliation | EMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche |
| Genetic information | This mouse line originates from EUCOMM ES clone CEPD0087_2_C10. For further details on the construction of this clone see the page at the IMPC portal. Quality Control/Disclaimer: The structure of the targeted mutation is not fully verified. It is recommended that the recipient confirms the mutation structure by Southern blotting. The Cre expression pattern is expected to mirror that of the host gene, but this may not be fully described and/or may be modified in the targeted allele. Although characterisation of the Cre expression pattern is an objective of EUCOMMTools this is an ongoing process which may be incomplete. It is therefore recommended that the recipient verifies the Cre expression pattern. For the tm2(EGFP/Cre/ERT2) type allele, if the promoter-driven selection cassette is flanked with Rox sites, it may be removed using Dre recombinase. Please be aware that the strain description may be subject to change. For the most recent description please consult the information pages for the appropriate product details at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased monocyte cell number / MGI
- decreased monocyte cell number / MGI
- extramedullary hematopoiesis / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- decreased metastatic potential / MGI
- decreased activated T cell number / MGI
- pancreas inflammation / MGI
- decreased tumor incidence / MGI
- abnormal hypersensitivity reaction / MGI
- abnormal dendritic cell physiology / MGI
- abnormal cell-mediated immunity / MGI
- abnormal neutrophil physiology / MGI
- abnormal type IV hypersensitivity reaction / MGI
- abnormal leukocyte migration / MGI
- abnormal leukocyte adhesion / MGI
- increased tumor growth/size / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- abnormal regulatory T cell physiology / MGI
- abnormal regulatory T cell number / MGI
- decreased T cell proliferation / MGI
- increased T cell proliferation / MGI
- decreased susceptibility to autoimmune disorder / MGI
- liver/biliary system phenotype / MGI
- immune system phenotype / MGI
- abnormal circulating protein level / MGI
- decreased single-positive T cell number / MGI
- lymph node hypoplasia / MGI
- intermingled spleen red and white pulp / MGI
- impaired neutrophil recruitment / MGI
- abnormal splenic cell ratio / MGI
- small popliteal lymph nodes / MGI
- abnormal cellular extravasation / MGI
- integument phenotype / MGI
- decreased response to antigen / MGI
- impaired leukocyte tethering or rolling / MGI